Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity (original) (raw)
1995, The Journal of Neuroscience
Abstract
AI
This study investigates the role of the left inferior prefrontal cortex (LIPC) in semantic encoding and repetition priming using functional magnetic resonance imaging (fMRI). Results indicate that semantic encoding is associated with increased LIPC activation, regardless of task difficulty, and that this area shows decreased activation during repeated semantic encoding due to process specificity. The findings suggest that the LIPC functions as part of a semantic executive system that supports the retrieval of semantic information.
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References (36)
- Abdullaev YG, Bechtereva NP (1993) Neuronal correlate of the higher- order semantic code in human prefrontal cortex in language tasks. Int J Psvchophysiol 14: 167-l 77.
- Baddeiey AD-(1986) Working memory. Oxford: Oxford UP Bandettini PA. Jesmanowicz A. Wona EC. Hvde JS (1993) Processing strategies for time-course data setFin functional MRI of the human brain. Magn Reson Med 30:161-173.
- Blaxton TA (1989) Investigating dissociations among memory mea- sures: support for a transfer-appropriate processing framework. J Exp Psycho1 Learn Mem Cognit 15:657-668.
- - Buckner RL, Petersen SE, Ojemann JG, Miezin FM, Squire LR, Raichle ME (1995) Functional anatomical studies of explicit and implicit memory retrieval tasks. J Neurosci 12:12-29.
- Cohen JD. Forman SD. Braver TS. Casev BJ. Servan-Schreiber D. No11 DC (1994) Activation of prefrontal cortex in a non-spatial working memory task with functional MRI. Human Brain Mapping 1:293- 304.
- Craik FIM, Lockhart RS (1972) Levels of processing: a framework for memory research. J Verb Learn Verb Behav 11:671-684.
- Craik FIM, Tulving E (1975) Depth of processing and the retention of words in episodic memory. J Exp Psycho1 Gen 104:268-294.
- Demonet JE Chollet F, Ramsay S, Cardebat D, Nespoulous JL, Wise R, Rascal A, Frackowiak R (1992) The anatomy of phonological and semantic processing in normal subjects. Brain 115:1753-1768.
- Desmond JE, Sum JM, Wagner AD, Demb JB, Shear PK, Glover GH, Gabrieli JDE, Morrell MJ (in press) Language lateralization in Wada-tested patients using functional MRI. Brain, in press.
- Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neu- rophysiol 61:331-349.
- Gabrieli JDE, Fleischman DA, Keane MM, Reminger SL, Morrell F (1995) Double dissociation between memory systems underlying ex- plicit and implicit memory in the human brain. Psycho1 Science 6:76- 82. Goldman-Rakic PS (1987) Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In: Handbook of physiology (Plum E Mountcastle V, eds), pp 373417. Bethesda, MD: American Physiological Society.
- Graf P, Schacter DL (1985) Implicit and explicit memory for new associations in normal and amnesic subjects. J Exp Psycho1 Learn Mem Cognit 11:501-518.
- Graf P, Squire LR, Mandler G (1984) The information that amnesic patients do not forget. J Exp Psycho1 Learn Mem Cognit 10:164- 178.
- Jonides J, Smith EE, Koeppe RA, Awh E, Minoshima S, Mintun MA (1993) Spatial working memory in humans as revealed by PET Na- ture 363:623-625.
- Kapur S, Craik FIM, Tulving E, Wilson AA, Houle SH, Brown GM (1994) Neuroanatomical correlates of encoding in episodic memory: levels of processing effect. Proc Nat1 Acad Sci USA 91:2008-2011.
- Keane MM, Gabrieli JDE, Fennema AC, Growdon JH, Corkin S (199 1) Evidence for a dissociation between perceptual and conceptual prim- ing in Alzheimer's disease. Behav Neurosci 105:326-342.
- Lee AT, Glover GH, Meyer CH (in press) Discrimination of large ve- nous vessels in time-course spiral blood-oxygen-level-dependent magnetic-resonance functional neuroimaging. Magn Reson Med, in press.
- Li L, Miller EK, Desimone R (1993) The representation of stimulus familiarity in anterior inferior temporal cortex. J Neurophysiol 69: 1918-1929.
- Marsolek CJ, Kosslyn SM, Squire LR (1992) Form-specific visual priming in the right cerebral hemisphere. J Exp Psycho1 Learn Mem Cognit 18:492-508.
- Mazoyer BM, Tzourio N, Frak V, Syrota A, Murayama N, Levrier 0, Salamon G, Dehaene S, Cohen L, Mehler J (1993) The cortical representation of speech. J Cognit Neurosci 5:467-479.
- McCarthy G, Blamire AM, Rothman DL, Gruetter R, Shulman RG (1993) Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proc Nat1 Acad Sci USA 90:49524956.
- McCarthy G, Blamire AM, Puce A, Nobre AC, Bloch G, Hyder E Goldman-Rakic P, Shulman RG (1994) Functional magnetic reso- nance imaging of human prefrontal cortex activation during a spatial working memory task. Proc Nat1 Acad Sci USA 91:8690-8694.
- Meyer CH, Hu BS, Nishimura DG, Macovski A (1992) Fast spiral coronary artery imaging. Magn Reson Med 28:202.
- Miller EK, Desimone R (1994) Parallel neuronal mechanisms for short- term memory. Science 263:520-522.
- Miller EK, Li L, Desimone R (1993) Activity of neurons in anterior inferior temporal cortex during a short-term memory task. J Neurosci 12:1460-1478.
- No11 DC, Cohen JD, Meyer CH, Schneider W (in press) Spiral k-space MRI of cortical activation. J Magn Reson Imag, in press.
- Paulesu E, Frith CD, Frackowiak RSJ (1993) The neural correlates of the verbal component of working memory. Nature 362:342-345.
- Petersen SE. Fox PT Posner MI. Mintun M, Raichle ME (1988) Pos- itron emission tomographic studies of the cortical anatomy of'single word processing. Nature 331585-589.
- Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME (1989) Pos- itron emission tomographic studies of the processing of single words. J Cognit Neurosci 1: 153-170.
- Petersen SE, Fox PT, Snyder AZ, Raichle ME (1990) Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. Science 249: 1037-104 1.
- Raichle ME, Fiez JA, Videen TO, MacLeod AK, Pardo JV, Fox PE, Petersen SE (1994) Practice-related changes in human brain func- tional anatomy during nonmotor learning. Cereb Cortex 4:8-26.
- Squire LR, Ojemann JG, Miezin FM, Petersen SE, Videen TO, Raichle ME (1992) Activation of the hippocampus in normal humans: A functional anatomical study of memory. Proc Nat1 Acad Sci USA 89: 1837-1841.
- Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the hu- man brain. Stuttgart: Thieme.
- Tulving E, Kapur S, Craik FIM, Moscovitch M, Home S (1994) Hemi- spheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings. Proc Nat1 Acad Sci USA 91:2016- 2020.
- Warrington EK, Weiskrantz L (1968) New method of testing long-term retention with special reference to amnesic patients. Nature 217:972- 974.
- Wilson FAW, O'Scalaidhe SP, Goldman-Rakic PS (1993) Dissociation of object and spatial processing in primate prefrontal cortex. Science 260:1955-1958.