Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer? (original) (raw)

Regucalcin, a calcium-binding protein, has been identified as a potential target gene in human prostate cancer due to its role in intracellular calcium homeostasis and its down-regulated expression in various carcinomas. This study investigates the expression of regucalcin in neoplastic versus non-neoplastic prostate tissues using RT-PCR, western blot, and immunohistochemistry techniques, revealing diminished expression in cancer cases and a negative correlation with cellular differentiation. The study further analyzes the effects of androgens, specifically 5-alpha-dihydrotestosterone, on regucalcin expression in prostate cancer cells, highlighting its potential involvement in tumor development and progression.