Antigens and Antigen-Presenting Molecules for γδ T Cells (original) (raw)

Springer eBooks, 1991

Abstract

The T cell receptor (TCR) γδ is expressed on a distinct subset of T cells (Brenner et al., 1986). Unlike the TCR αβ, little is known about γδ T cell recognition. TCR α and s and TCR γ and δ genes are assembled during development by recombination of distinct gene segments (V, D, J). While the germline gene segment repertoire for both TCR γ and δ chains is small compared to the TCR αs, extensive junctional diversity is observed particularly in the TCR δ chain (reviewed in Brenner et al. 1988). The diversity resides in a region presumed to form the CDR3 homolog of the immunoglobulin molecule considered important in antigen recognition (Davis and Bjorkman, 1988). These structural features of the γδ TCR suggest a role for T cells bearing this receptor in specific antigen recognition.

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