Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: Attenuated nitric oxide and thromboxane B production in endotoxemia (original) (raw)

Abstract

Estradiol plus progesterone (EP) implants have been shown to favorably alter the time course or decrease the severity of many of the clinical manifestations associated with coccidiosis and endotoxemia in calves. This study evaluated the effect of EP treatment on plasma tumor necrosis factor-α (TNF), thromboxane (TXB), prostacyclin (PRC), nitrite and nitrate (NO [x]), and cortisol. Holstein steer calves were divided into four groups: control, EP, endotoxin (LPS), and EP+LPS (n = five/group). Estradiol/progesterone pellets (Synovex-S) were implanted subcutaneously when calves reached 20 wk of age. One week after implantation, calves were injected IV with endotoxin (i.e., lipopolysaccharide; LPS, 0.6 g/kg of BW) or nonpyrogenic saline placebo. Body temperature was measured and blood was collected before injection and at 1, 2, 3, 4, 6, and 8 h thereafter. Plasma concentrations of TNF,

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