Creatine supplementation to treat "muscle wasting" in rheumatoid arthritis patients (original) (raw)
Related papers
Arthritis Care & Research, 2016
• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy This is the peer reviewed version of the following article: "Can creatine supplementation improve body composition and objective physical function in rheumatoid arthritis patients? A randomised controlled trial", which has been published in final form at http://dx.doi.org/10.1002/acr.22747\. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Amino Acids, 2012
Background and objectives. Patients with rheumatoid arthritis (RA) frequently suffer from muscle weakness. Oral administration of creatine has been shown to improve muscle strength in healthy subjects. The objective of this study was to examine the effect of oral creatine supplementation on muscle weakness, disease activity and activities of daily living in patients with RA. Methods. During a period of 3 weeks, 12 patients with RA were treated with creatine monohydrate (20 g/day for 5 days followed by 2 g/day for 16 days). They were examined on entry and at the end of the study. The patients were investigated clinically, blood and urine samples were obtained, muscle biopsies were performed before and after treatment, muscle strength was determined, and self-administered patient questionnaires were completed. Results. From all patients we were able to obtain full clinical and questionnaire data, while biopsies were taken from 12 patients at the start and from nine patients at the end of the study. Muscle strength, as determined by the muscle strength index, increased in eight of 12 patients. In contrast, physical functional ability and disease activity did not change significantly. The creatine concentration in serum and skeletal muscle increased significantly, while creatine phosphate and total creatine did not increase in skeletal muscle. The skeletal muscle creatine content was associated with muscle strength at baseline but not after administration of creatine. The changes in muscle strength were not associated with the changes in skeletal muscle creatine or creatine phosphate. Conclusion. Although the skeletal muscle creatine content and muscle strength increased with creatine administration in some patients with RA, a clear clinical benefit could not be demonstrated for this treatment when the patients were considered as one group.
2008
The purpose of this study was to examine the effects of 6 weeks of oral creatine supplementation and a high-protein diet on muscular strength and body composition. Thirty-six college athletes (at least 1 year of weight training experience) volunteered to take part in the study. They were randomly assigned to one of four groups: creatine and protein (Cr + Pro, n=9), creatine (Cr, n=9), protein (Pro, n=9), and placebo (P, n=9). They showed no significant difference in their pretest values. Cr consumed 5 g of creatine monohydrate in a flavored sucrose drink four times per day for 6 day. After 6 days, supplementation was reduced to 5 g.d-1.Cr +Pro ingested Cr in a same procedure plus a high protein diet (1.6 g.kg/day).Pro ingested placebo plus a high protein diet (1.6 g.kg /day). Placebo ingested a starched, sucrose drink. 1RM strength of arm flexors, bench press, squat and body composition was measured before and after a 6-wk resistance training program. The subjects trained (3 day.Week-1) with determined training loads. Results showed that body mass and lean tissue mass increased to a greater extent with training in Cr + Pro compared to the other groups, and in Cr compared to P group (p< 0.05). There were no significant changes in percent body fat for groups. Cr + Pro group demonstrated greater improvement in 1RM of squat, bench press and arm flexors than other groups. Also, subjects who supplemented with Cr + Pro had similar increases in 1RM of squat, bench press compared to placebo group (p< 0.05). There were not significant differences between Cr supplementation and high protein diet on muscular strength and body composition.
Arthritis & Rheumatism, 2007
To test the hypothesis that oral creatine supplements with exercise are more effective than exercise alone in improving muscle function in patients with established dermatomyositis or polymyositis receiving chronic medical therapies who are clinically weak yet stable. Methods. In a 6-month, 2-center, double-blind, randomized controlled trial, patients were randomized to receive oral creatine supplements (8 days, 20 gm/day then 3 gm/day) or placebo. All patients followed a home exercise program. The primary outcome was aggregate functional performance time (AFPT), reflecting the ability to undertake high-intensity exercise. Secondary outcomes included a functional index measuring endurance and muscle bioenergetics on 31 P magnetic resonance spectroscopy ( 31 P MRS). Patients were receiving stable immunosuppressive treatment and/or corticosteroids. Results. A total of 37 patients with polymyositis or dermatomyositis were randomized (19 to creatine, 18 to placebo); 29 completed 6 months. Intent-to-treat analyses demonstrated that AFPT improved significantly at 6 months with creatine (median decrease 13%, range -32-8%) compared with placebo (median decrease 3%, range -13-16%; P ؍ 0.029 by Mann-Whitney U test). A completer analysis also showed significant benefits from creatine (P ؍ 0.014). The functional index improved significantly with both creatine and placebo (P < 0.05 by paired Wilcoxon's rank sum test), with a significant benefit between groups in the completer analysis only. Phosphocreatine/-nucleoside triphosphate ratios using MRS increased significantly in the creatine group (P < 0.05) but not in the control group. No clinically relevant adverse events were associated with creatine. Conclusion. Oral creatine supplements combined with home exercises improve functional performance without significant adverse effects in patients with polymyositis or dermatomyositis. They appear safe, effective, and inexpensive.
EFFECTS OF CREATINE MONOHYDRATE (CR) TO MUSCLE STRENGTH AND BODY COMPOSITION
Bojan Bjelica , Borislav Cicović, Dalibor Stević, Rosario D'Onofrio , Tijana Perović , Radomir Pržulj , Nebojša Mitrović Ita. J. Sports Reh. Po., 2020
Aim of research was to examine the effects of consuming CR to muscle strength and body composition. Duration of experimental treatment was 8 weeks. Sample consisted of 14 participants aged 24±6months divided into two sub-samples: 6 participants who consumed CR and 8 participants who were placebo group. Strength was assessed using 3 tests: Bench Press 1RM, Leg Press 1RM, and Barbell Biceps Scott – maximum number of repetitions with 15kg load. Following parameters were obtained for the purpose of assessment of body composition: Body mass, Muscle mass, Body Fat, Body Water. Assessment of body composition was performed using bioelectric impedance TANITA BC-545n. Differences between the groups were assessed by ANOVA test of repeated measures. Upon taking insight into the results we may conclude that CR influences changes in body composition: Body mass (.000), Muscle mass (.039), Body Water (.010); effects to Body Fat are not statistically significant. In placebo group changes were noticed only in variable Body Water (.007). Effects to body strength were confirmed in all three variables: Bench Press (.050), Leg Press (.041), Barbell Biceps Scott (.003)., whereas no significant changes were observed in placebo group. CR is efficient dietary supplement for both professional and amateur athletes. Citation. Bojan Bjelica , Borislav Cicović, Dalibor Stević, Rosario D'Onofrio , Tijana Perović , Radomir Pržulj , Nebojša Mitrović ; Effects of creatine monohydrate (CR) to muscle strength and body composition ; Ita. J. Sports Reh. Po.; 2020; 7; 3; 1624 -1637 ; ISSN 2385-1988 [online] IBSN 007-111-19 - 55; CGI J OAJI 0,101)]
Rheumatoid Arthritis - Treatment, 2012
Whilst the causes of disability in RA are multifactorial (Escalante & del Rincon, 1999, 2002), Giles et al. (2008) has shown that it is strongly associated with adverse changes in body composition, with HAQ scores inversely related to appendicular lean mass (ALM; a surrogate measure of muscle mass) and directly related to total and appendicular fat masses. Subsequently, Stavropoulos-Kalinoglou et al. (2009) have also shown that obesity is significantly and independently associated with disability in RA patients. Such links between body composition and physical function are not surprising as they reflect those observed in the general elderly population, whereby classification as either muscle-wasted (sarcopenic) or obese significantly exacerbates the likelihood of disability, whilst the coincidence of both conditions (sarcopenic-obesity) increases disability risk 12-fold in women and 9-fold in men (Morley et al., 2001). 2.2 Rheumatoid cachexia Unfortunately, both reduced muscle mass and elevated adiposity, termed "rheumatoid cachexia" (Roubenoff et al., 1992), are characteristic of RA. Muscle wasting due to RA was first observed by Sir James Paget in 1873 and has been consistently reported in recent decades (see
Effects of Creatine Monohydrate to Strength and Body Composition
SPORT I ZDRAVLJE, 2020
Creatine has become highly popular supplement among athletes. Contemporary research also suggests that there is also a large number of potential therapeutic applications of creatine. Aim of this systematic overview is to test the effects of CR to muscle strength and body composition on the basis of the collected data and analysed papers published in the period 2018–2020. Literature research was performed in the following data bases: PubMed, Scholar Google and DOAJ. Papers were selected according to multiple criteria and they suggest that CR in combination with an exercise program produces results in increase of muscle mass and strength and it reduces time required for execution of a specific activity. Changes in body composition were observed in increase of total mass and muscle mass, as well as amount of water in body composition. Use of CR in amount of 10-20 g per day and frequency of 4–5 days a week is an efficient tool used for increase in sport performances and positive changes...
EFFFECTS OF CREATINE MONOHYDRATE TO STRENGTH AND BODY COMPOSITION
ARTICLE Abstract: Creatine has become highly popular supplement among athletes. Contemporary research also suggests that there is also a large number of potential therapeutic applications of creatine. Aim of this systematic overview is to test the effects of CR to muscle strength and body composition on the basis of the collected data and analysed papers published in the period 2018-2020. Literature research was performed in the following data bases: PubMed, Scholar Google and DOAJ. Papers were selected according to multiple criteria and they suggest that CR in combination with an exercise program produces results in increase of muscle mass and strength and it reduces time required for execution of a specific activity. Changes in body composition were observed in increase of total mass and muscle mass, as well as amount of water in body composition. Use of CR in amount of 10-20 g per day and frequency of 4-5 days a week is an efficient tool used for increase in sport performances and positive changes in body composition.
Exploring the therapeutic role of creatine supplementation
Amino Acids, 2010
Creatine (Cr) plays a central role in energy provision through a reaction catalyzed by phosphorylcreatine kinase. Furthermore, this amine enhances both gene expression and satellite cell activation involved in hypertrophic response. Recent findings have indicated that Cr supplementation has a therapeutic role in several diseases characterized by atrophic conditions, weakness, and metabolic disturbances (i.e., in the muscle, bone, lung, and brain). Accordingly, there has been an evidence indicating that Cr supplementation is capable of attenuating the degenerative state in some muscle disorders (i.e., Duchenne and inflammatory myopathies), central nervous diseases (i.e., Parkinson’s, Huntington’s, and Alzheimer’s), and bone and metabolic disturbances (i.e., osteoporosis and type II diabetes). In light of this, Cr supplementation could be used as a therapeutic tool for the elderly. The aim of this review is to summarize the main studies conducted in this field and to highlight the scientific and clinical perspectives of this promising therapeutic supplement.