Association between serum alpha-fetoproteinlevel and liver function parameters in hepatocellular carcinoma patients: A case-control study (original) (raw)
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Journal of IMAB - Annual Proceeding (Scientific Papers)
In this study, we analyzed biochemical parameters in the serum of patients with a diagnosis of hepatocellular carcinoma (HCC) C and B viral etiology. Material/Methods: All patients (31 males and 20 females) with a diagnosis of HCC that were treated at the Clinical Centre of the University of Sarajevo were included in this retrospective-prospective study. Serum alphafetoprotein was analyzed as a tumor marker, and hepatitis markers included HBs Ag, anti-HBs, anti-HBc, anti-HCV and anti-HB. Spearman test and Kolmogorov-Smirnov test were used for correlation and normality analysis, respectively. Results: The largest number of patients (68.62%) had cirrhosis of C viral etiology that developed in cancer. Hepatocellular carcinoma was diagnosed more in men than in women (60.78%). The most patients were middle-aged (41-64 years). HCC was present in the right liver lobe at 82.85% HCV and 87.5% HBV patients. Only 6.25% of HBV patients were both liver lobes affected. All biochemical parameters had very high values, especially AFP and ãGT. Significant differences for AST and ALT were found between men and women. Serum bilirubin levels (total, direct and indirect) and AP are higher in men than women. Hepatitis markers had high values, and the incidence of HBs Ag (78%) and anti HBc (78.72%) was established. Conclusions: A positive correlation was established between AFP and other parameters, while a significant difference between AFP and γGT (r = 0.372, p = 0.008) was confirmed. In addition to imaging methods for determining liver cirrhosis and hepatocellular carcinoma, high values of AFP and γGT, are a powerful diagnostic marker for these diseases.
Open Access Macedonian Journal of Medical Sciences, 2018
BACKGROUND: AFP serum levels are considered as diagnostic and specific for hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). AIM: This study aimed to examine the diagnostic value of AFP in the distinguishing of patients with HCC from patients with LC, and to analyse the potential correlation between AFP levels and liver disease stages. MATERIAL AND METHODS: Fifty patients with LC and fifty patients with HCC were included in this study. The majority of the patients were males, while the HBV aetiology was dominant. RESULTS: Significant differences between LC and HCC patients were detected for AST, ALT, GGT, bilirubin, AFP and AP. Patients with HCC had higher AFP values compared to LC. There was no significant correlation between the size of the tumour lesion and serum AFP levels. A positive correlation between AFP concentration and GGT activity was determined, as was the negative correlation between AFP and age of the subjects. The AFP value of 23.34 ng/m showed hi...
Cancer, 2014
BACKGROUND: a-Fetoprotein (AFP) is a biomarker commonly used in the management of patients with hepatocellular carcinoma (HCC), although the possible determinants of its serum levels in these patients have not been adequately explored. For this study, the authors evaluated the relevance of demographic, clinical, and oncologic factors to the presence of elevated AFP levels in large cohort of patients with HCC. METHODS: In 4123 patients with HCC who were managed by the Italian Liver Cancer Group, AFP levels were assessed along with their association with demographic, biochemical, clinical, and oncologic characteristics. Patients were subdivided according to the presence of elevated AFP (ie, >10 ng=mL). RESULTS: AFP levels were elevated in 62.4% of patients with HCC. Multivariate logistic regression analysis indicated that being a woman (odds ratio [OR], 1.497; 95% confidence interval [95%CI], 1.250-1.793; P <.0001), the presence of cirrhosis (OR, 1.538; 95% CI, 1.050-2.254; P 5.027), liver disease with viral etiology (OR, 1.900; 95% CI, 1.589-2.272; P <.0001), an elevated alanine aminotransferase level (OR, 1.878; 95% CI, 1.602-2.202; P <.0001), a low albumin level (OR, 1.301; 95% CI, 1.110-1.525; P 5.012), an HCC tumor size >2 cm (OR, 1.346; 95% CI, 1.135-2.596; P 5.001), multinodular HCC (OR, 1.641; 95% CI, 1.403-1.920; P <.0001), and the presence of vascular invasion (OR, 1.774; 95% CI, 1.361-2.311; P <.0001) were associated independently with elevated levels of AFP. Both the median AFP level and the proportion of patients who had elevated levels Original Article increased with decreasing degrees of HCC differentiation (P <.0001). CONCLUSIONS: Sex and features of chronic liver disease were identified as nontumor characteristics that influence serum AFP levels in patients with HCC. These findings should be taken into account as limitations in interpreting the oncologic meaning of this biomarker in clinical practice. Cancer 2014;120:2150-7.
International Journal of Clinical Biochemistry and Research
Serum AFP as a poor clinical performance values especially when it comes to deal with the early and AFP-negative diagnostic of HCC. The aim of this work was to assess the contribution of AFP in the diagnosis of HCC. : A total of 95 subjects was enrolled a prospective observational study by consecutive enrolment and divided in two groups. The first group was made up with subjects in whom the diagnosis of HCC had been retained while the second was the control group which was free of HCC. AFP levels were performed by electrochemiluminescence immunoassay on the cobas e411. Data were captured in Excel and analyzed by Ri386 version 4.1.2 binary for macOS 10.13. The Log of median of AFP in HCC subjects was significantly greater than in non HCC subjects 6.91 ng/mL versus 1.43 ng/mL, Wilcoxon < 0.001. At the cut-off of 200 ng/mL, the clinical performances showed an acceptable sensitivity 97.1% CI 95% [93.7 – 100] but a poor specificity 73,8% CI 95% [64.9 – 82.6] and out of the 34 cases of...
BMC Cancer, 2007
Background: Hepatocellular carcinoma is the most common cause of primary liver neoplasms and is one of the main causes of death in patients with liver cirrhosis. High Alpha fetoprotein serum levels have been found in 60-70% of patients with Hepatocellular carcinoma; nevertheless, there are other causes that increase this protein. Alpha fetoprotein levels ≥200 and 400 ng/mL in patients with an identifiable liver mass by imaging techniques are diagnostic of hepatocellular carcinoma with high specificity.
Hepatocellular carcinoma (HCC) and diagnostic significance of A-fetoprotein (AFP)
Journal of Ayub Medical College, Abbottabad : JAMC
Alpha-fetoprotein (alpha-fetoprotein, AFP) is a Glycoprotein, belonging to the intriguing class of onco-development protein. Generally designated as tumour marker, AFP is recognized as an important blood component, having specific diagnostic utilities Elevation of its level up to pathological range in adults correlate with the appearance of several malignant and chronic conditions, such as hepatocellular carcinoma (HCC) and chronic liver disease, respectively. To evaluate the diagnostic significance of AFP in HCC, a study was carried out for a period of two years (Jan 2004 to Dec 2005) A brief history of Patients was taken with clinical symptoms and signs and initial diagnosis. Patients admitted in wards or visiting OPDs with diagnosis or suspicions of HCC and additional conditions of Chronic Liver disease (CLDs), hepatitis C (HCV) and hepatitis B viral (HBV) infections, were selected and classified according to gender. When confirmed, their HCC status was evaluated and classified a...
Corelation of serum alpha fetoprotein and tumor size in hepatocellular carcinoma
JPMA. The Journal of the Pakistan Medical Association, 2012
To determine the correlation of elevated serum Alpha feto-protein with tumour size in hepatocellular carcinoma. A cross-sectional analytical study was done at Jinnah Postgraduate Medical Centre, Karachi, Medical Unit-III, Ward-7 from January 2009 to June 2010. Patients enrolled in study were known cases of chronic liver disease and were complicated by development of hepatocellular carcinoma; those having metastasis in liver from any where were excluded. Demographic data such as age, gender, residence, were recorded. Detailed clinical history and examination were carried out and recorded in a preformed Performa. Complete blood count, liver function test, total protein, Albumin/Globulin (A/G) ratio, serum Albumin, HBsAg, anti HCV, alpha fetoprotein, ultrasound guided liver biopsy, ultrasound whole abdomen and/or CTscan Abdomen for size and number of tumour were also done. On the basis of alfa fetoprotein level patients were divided in to 3 groups; Group I with normal AFP (< or = 20...
Background: This study aims to determine the value of using Alpha Fetoprotein for early detection of Hepatocellular Carcinoma among patients with chronic liver disease in African population. Methods: 50 patients with clinical and radiological evidence of Chronic Liver disease attending the gastroenterology clinic of Aminu Kano Teaching Hospital and 50 healthy volunteers were recruited by systematic sampling over 3 months. The patients were grouped according to their definitive diagnosis into: Hepatocellular carcinoma, Hepatitis B and C co-infection, Hepatitis B infection, Hepatitis C infection, Liver cirrhosis and unclassified/Miscellaneous. Alpha fetoprotein was assayed using an Electrochemiluminescence Immunoassay. Results: Hepatocellular carcinoma accounted for 22% of the study group, while Hepatitis B and C co-infection 16%, Hepatitis B infection 12%, Hepatitis C infection 6%, Liver cirrhosis 34% and Miscellaneous group 10%. The validity of Alpha Fetoprotein for Hepatocellular Carcinoma at a cut-off value of >200IU/L were: Sensitivity- 73%, specificity-100% and predictive value positive-100% respectively. Conclusion: AFP is useful for early detection of HCC in CLD patients’ of African descent.
2021
Materials & Methods: This cross-sectional descriptive study was conducted in Rehman Medical Institute, Peshawar, Pakistan from January 2018 till December 2019. Data were gathered from the medical records of Endoscopy Unit of Rehman Medical Institute. Patients were separated into three groups on the basis of serum AFP levels: Group I had standard levels of AFP (<20 IU/ml), Group II had moderately raised AFP (20-399 IU/ml), and Group III had significantly raised AFP (>400 IU/ml). Patients were also separated into three groups on the basis of tumor; in Group A tumor size was less than 3 cm, in Group B it was between 3 and 5 cm, and in Group C the size was greater than 5 cm. For categorical variables, the Chi-square and Z test for proportions were applied; the Wilcoxon Rank-Sum (Mann-Whitney) test was used to evaluate the variation in the two categories, and the Kruskal-Wallis Rank test was used to evaluate the difference between categories. A p value ≤0.05 was taken as significan...