FeCl3•6H2O catalyzed three components aza-Friedel-Crafts reaction For the synthesis of N-Boc protected α-branched amines (original) (raw)

FeCl 3 •6H 2 O is shown to be an efficient catalyst for the three component aza-Friedel-Crafts reaction of arenes or heteroarenes, tert -butyl carbamate, and aromatic aldehydes under mild conditions. In the presence of 5 mol % of FeCl 3 •6H 2 O in toluene at room temperature, the reaction of 1,3,5-trimethoxybenzene, 2-methyl furan, and 2-ethylfuran gave the corresponding N -Boc protected α-branched amines, selectively, in moderate to excellent yields. However, the reaction of the less reactive 2-methylthiophene afforded the α-branched amine adducts in low yield. On the other hand, the reaction of indole gave the triarylmethane as major product. The use of mild reaction condition, commercially available as well as inexpensive catalyst, low catalyst loading, and single step synthesis are the advantage of the presence procedure.

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