Primary cutaneous follicle center lymphoma: A case report (original) (raw)
Related papers
An unusual presentation of primary cutaneous follicle center lymphoma
Experimental Oncology, 2021
Summary. Primary cutaneous follicle center lymphoma (PCFCL) is a rare low-grade cutaneous B-cell lymphoma. Clinically, PCFCL is usually an erythematous subcutaneous nodule or an infiltrated plaque. The dermoscopy is non-specific and it is characterized by polymorphous vascular pattern, arborizing vessels over a salmon-colored background and white areas. We reported a case of a 36-year-old woman presented with a rapidly growing, flashed-color, exophytic, soft consistency nodule on her scalp. Dermoscopy showed a diffuse structureless, skin-color area associated with a rare arborizing vascular pattern and brown circles. We reported a peculiar clinical and dermoscopic variant. This clinical presentation of PCFCL is unusual and represents a pitfall in the early clinical diagnosis. Histopathology is mandatory for a correct diagnosis.
Are there any Dermoscopic Signs of Primary Cutaneous Follicular Center B-cell Lymphoma
Cutaneous follicular center B-cell lymphoma is an indolent tumor that arise on head or neck. Histology by immunotyping with monoclonal antibodies in frozen or paraffin - embedded tissue is necessary for diagnosis. The tumor is usually treated by surgery or radiotherapy, although other treatments may be used such as interferon-α, chemotherapy, and biological agents. We report the case of a 70-year-old woman C, having a son followed in our department for Primary cutaneous follicular center B-Cell lymphoma who consulted for erythematous tumour in the temporal region that exhibit special features in dermoscopy and who was diagnosed with cutaneous follicular center B-cell lymphoma after biopsy, laboratory tests, thoracic-abdominal-pelvic computed tomography and abdominal ultrasound. These observation provide a first indication that early stage PCFCCL exhibits a characteristic dermoscopic pattern which is different. Prospective studies with long term follow-up are needed to determine the value of these dermoscopic.
Intractable & Rare Diseases Research
Primary cutaneous follicle center lymphoma (PCFCL) is defined as a low-grade B-cell non-Hodgkin's lymphoma, which primarily occurs and remains confined to the skin, without evidence of extracutaneous or systemic involvement at the time of diagnosis. PCFCL affecting the breast skin is an exceedingly rare entity with only two cases reported in the English literature. We present a case of PCFCL affecting the periareolar breast skin and review the relevant literature. Our patient was a 64-year-old female who presented with an erythematous plaque in the periareolar region of the left breast. The diagnosis of PCFCL was confirmed by a biopsy performed with a seven-month delay, as the tumor had been initially misdiagnosed as a benign lesion. The patient was successfully treated with local radiation therapy. PCFCL is an indolent lymphoma associated with an excellent prognosis. For localized lesions, skin-directed therapies mainly consisting of radiation therapy or complete surgical excision are curative therapeutic approaches, while systemic chemotherapy should be reserved for patients with extensive disease. This case highlights the need to consider PCFCL as an important differential diagnosis in patients presenting with non-resolving erythematous breast skin lesions. A timely biopsy should be obtained to avoid delays in the initiation of appropriate treatment.
Case Reports in Medicine, 2010
Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man with a gastric diffuse large B-cell lymphoma (DLBCL) referred to our clinic because of nodules in the back that had gradually developed over a period of 10 years. A biopsy performed 3 years before was interpreted as reactive follicular hyperplasia. A new skin biopsy revealed a diffuse large B-cell lymphoma and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal rearrangement was detected which was highly suggestive of a transformation lymphoma.
Primary cutaneous follicle centre lymphoma presenting as diffuse facial erythema
Journal of the European Academy of Dermatology and Venereology, 2014
nocardiosis, leishmaniasis, tularaemia and other deep fungal or bacterial infections. Diagnosis in these cases is usually established on histopathology, including special stains and culture. However, histology in our patient revealed malignant mesenchymal tumour which was subsequently confirmed on IHC. To the best of our knowledge, this type of presentation of MPNST has not been reported in literature and we suggest the inclusion of MPNST in the differential diagnosis of multiple linear nodules presenting in a sporotrichoid distribution so that an early recognition of this condition can prevent the morbidity and mortality ultimately associated with dissemination.
Case Reports in Hematology, 2017
An elderly woman with a complex medical history presented with a left forearm mass that slowly developed for several months. The excisional biopsy of this skin mass was remarkable for involvement by a follicle centre cell derived lymphoma with a nodular and diffuse pattern associated with a subset of scattered Hodgkin and Reed-Sternberg like cells. Fluorescence in situ hybridization studies did not detect the presence of IgH-bcl2 fusion transcript, and molecular studies were negative for immunoglobulin heavy chain gene rearrangements and EBV DNA sequences. Hodgkin and Reed-Sternberg like cells are rarely reported in FLs, and the association with primary cutaneous follicle centre lymphoma is extremely rarely seen. To our knowledge, our case is the second case of primary cutaneous follicle centre lymphoma with Hodgkin and Reed-Sternberg like cells.
Primary cutaneous B-cell lymphomas: recent advances in diagnosis and management
Cancer control : journal of the Moffitt Cancer Center, 2012
Primary cutaneous B-cell lymphoma (PCBCL) is a heterogeneous group of rare clonal B-cell lymphoproliferative disorders with distinct clinicopathologic features from more common nodal B-cell lymphomas. We performed a systematic review of the relevant literature in the MEDLINE database and analyzed laboratory and clinical data. This review discusses the three most common types of PCBCL: primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle-center lymphoma (PCFCL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). Skin biopsies with histology, immunohistochemistry, and molecular clonality studies are essential for a correct diagnosis of cutaneous B-cell lymphoma. Comprehensive lymphoma staging with laboratory and imaging studies and bone marrow aspiration and biopsy are important for determining the prognosis and differentiation of PCBCL from secondary skin involvement with systemic B-cell lymphomas. PCMZL and PCFCL are low-grade PCBCLs...