Alternative Treatment of Bacterial Wound Infections (original) (raw)

2022, Magazine of Al-Kufa University for Biology

Topical and systemic antibiotic treatment are essential in the prevention and treatment of wound infections. Systemic antibiotics, on the other hand, are strongly linked to mechanisms of resistance, which jeopardize the treatment process. The direction of systemic antibiotics to the eschar becomes less reliable the deeper the burn and the thicker the eschar becomes for local wound care (Noronha and Almeida, 2000). As a result, topical antibiotics appear as a viable treatment option, as they help to maintain a "high and sustained concentration of the antimicrobial at the infection site" (Cowling and Jones, 2017). Every year, wound treatment develops a high urgent clinical problem, as The requirement for wound care has an influence on a significant percentage of the global population. The system of healthcare in the United States spends $20 million a year on wounds (Jackson, 2006). An Incisional, acute, and chronic wounds are all examples of wounds that can become infected and lead to more complications. Incisional wounds and deep lacerations are often troublesome, and they account for a significant portion of the annual cost of wound healing products. While Wounds from incisions heal more quickly than chronic wounds, they always have challenges with appropriate closure as well as the formation of granulation tissue, which might lower one's quality of life. Wounds from incisions are also susceptible to infection, necessitating further care. Antiseptics, antibiotics, as well as silver dressings have traditionally is always used to treat wounds, however each of these therapies is ineffective against a wide range of microorganisms often present in wounds. However, if no appropriate clinical intervention is used, skin regeneration and overall healing time would be significantly slowed. While It's possible to use recombinant growth factors and tissue-engineered wound dressings, they are extremely costly and out of reach for the majority of illnesses (Shevchenko et al., 2010). In extreme burns, (SSD) silver sulfadiazine is the preferred transdermal substance, and it is almost universally used today over silver nitrate as well as mafenide acetate. Although SSD cream works excellent., it can effect recurrent side effects such as erythema multiforme, neutropenia, methemoglobinemia, and crystalluria (Hosnuter et al., 2004). As a result of this restriction, there has been an increase in interest in the development of a suitable biological wound care dressing that can provide the appropriate milieu for wound healing as well as protection during the process of healing. It possesses antifungal, antimicrobial, additionally antibacterial characteristics, which are particularly effective in wound care. It also increases the host's defenses to avoid infection. (Azuma et al., 2015). Several research groups around the world are