Classification of angioedema without wheals (original) (raw)
2016, Annals of Allergy, Asthma & Immunology
AI-generated Abstract
The article discusses the off-label treatment of idiopathic nonhistaminergic acquired angioedema (InH-AAE) with omalizumab, highlighting the need for improved classification of angioedema types. It critiques the term "nonhistaminergic" as misleading, emphasizing the heterogeneous nature of InH-AAE and the varying responses to treatments. The authors propose a clearer classification based on endotypes, distinguishing between mast cell-mediated and bradykinin-mediated angioedema, and call for further evidence to validate diagnostic criteria.
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