Retrospective histological analysis of CNS tumors - A 5 year study (original) (raw)
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Spectrum of Central Nervous System Tumors-A Four Year Study In A Tertiary Care Center
2018
Introduction: Tumours of central nervous system constitute 1%-2% of tumours in adults. Few studies are available from India which show a lower incidence of brain tumours compared to the developed countries. Not much is known about the epidemiology of brain tumours in South Indian population. Aim: To identify the age and gender distribution, different histological types and grades of brain tumours according to 2016 WHO classification. Material and Methods: A retrospective study of 122 cases of brain tumours over a period of four years was done. We reclassified and graded the tumors based on 2016 WHO classification. Age and gender distribution, clinical presentation, site of tumour and histopathologic patterns with grade were noted and the data was analysed. Results: Predominant age group affected was between 40-50 years, with a male to female ratio of 1.14:1. Diffuse Astrocytic tumors were the most common type, followed by Meningiomas. Majority of cases were of WHO grade II and invol...
Journal of National Institute of Neurosciences Bangladesh
Background: Glioma is the most commonly occurring malignant brain tumor that varies by age, sex, race or ethnicity. A very few number of records on CNS tumors are available in Bangladesh. National Institute of Neurosciences and Hospital (NINS), Dhaka has a good number of CNS surgeries. Regularly both tumorous and non-tumorous ICSOL samples are examined here. Objective: The aim of the study was to see the subtypes, frequency and topography of Astrocytic tumors at NINS setting. Methodology: Data from the department of Neuropathology department of NINS since January 2013 to June 2019 were evaluated. Tissue were fixed in formalin, paraffin embedded, stained with H&E. Histomorphology and WHO 2007 CNS tumor classification were used. Result: From 3945 routine sample 567 cases were sorted out as Astrocytic tumor. Total male were 61% (346) and female 39% (221), male to female ratio was 1.6:1. The mean age was 32.64 and ranged from 1 to 80 years. Sixty six percent (66%) tumors were in suprate...
Spectrum of Brain Tumors in a Tertiary Care Hospital: A 5 Years Study
Background-Tumor epidemiology is a significant part in case of intracranial tumor studies. Here, we discuss the features of intracranial tumor pathology in single centre. Aims and Objective-To analyze the age,sex and site wise distribution of different histological pattern of intracranial tumors seen in our centre. Materials and Methods-It is a retrospective study of cases of intracranial tumors seen over a period of 5 years .Altogether 160 CNS specimens were fixed in 10% Formalin and processed in automatic tissue processor. Routine Hematoxylin and Eosin stain and special stains were done and examined under the light microscope. The diagnosis is given on the basis of age,sex distribution using the WHO grading and the histological subtypes.Results-Out of total 160 cases of intracranial tumor 86 cases were of meningioma (53.75%). 30 cases were of astrocytoma (18.75%).13 cases are of pituitary adenoma (8.125%) .11 cases were of schwannoma (6.875).5 cases were of glioblastoma grade 4 (3.125%).5 cases were of oligodendroglioma grade 2 (3.125%).2 cases were of each metastatic carcinoma, ependymoma,cerebellar hemangioblastoma and tuberculoma (1.25%).1 case of each central neurocytoma and craniopharyngioma (0.625%).In this study meningioma is the most common intracranial tumor followed by astrocytoma.Conclusion-Meningiomas are commonest tumor and comprise more than half of all operated CNS tumors in our setup, followed by astrocytomas.Meningothelial Meningioma is the most common subtype.This study can help in observing CNS tumor trends and changing patterns.
Incidence of the Histological Types of Tumors of the Central Nervous System
International Journal of Science and Research (IJSR), 2017
Background: The tumors of the Central nervous system (CNS) include tumors of the brain and spinal cord. Primary CNS tumors are not common. However the incidence of CNS tumors has been rapidly increasing at recent times. 1 Aims and Objectives: The aims of this study were to determine the relative frequencies of tumors of central nervous system (CNS), their age and sex distribution. It was a hospital based study. Methods: The study group comprises of a total of 60 cases of tumors of CNS who have been clinically and radiologically diagnosed as such in the department of Neurosurgery, department of Pediatric surgery and department of General surgery in GMCH.The patients are of all ages and both sexes who have been operated for clinically indicated reasons. Result: CNS tumors are more common in adults with 50 cases (83%) than children with 10 cases (17%). Tumors of the CNS are more common in males than females in both children (≤19 years) and adults (>19 years) with a M:F ratio of 1.5:1 and 1.17:1 respectively. In adults meningioma was the commonest histology among all primary CNS tumors with 22 cases (44%). In children astrocytomas were found to be the commonest with 6 cases (60%). In adults the most common site of CNS tumor was found to be meninges (23 cases, 46 %). In children the most common site was cerebellum (6 cases, 60 %). Intracranial tumors were more common with 48 cases (80%) than spinal cord tumors with 12 cases (20%). Among the spinal cord tumors meningioma was the most common (8 cases, 66.7%) followed by schwannoma (3 cases, 25%) and ependymoma (1 case, 8.3%). Conclusion: CNS tumours vary considerably in their histological and gender distribution throughout childhood and adulthood. CNS tumors in adults have a relatively high frequency as compared to children. Even though most patients with high grade gliomas have a dismal prognosis, long-time survivors are seen in all histologic groups and illustrate the heterogeneity of these tumors. 2
A diversity of central nervous system tumours at a tertiary care centre-a one year prospective study
IP Innovative Publication Pvt. Ltd., 2017
Introduction: Central nervous system tumours represent unique heterogenous population of neoplasms which include both Benign and Malignant neoplasms. In India, CNS tumours constitute about 1.9% of all the tumours. These tumours pose diagnostic difficulty due to varied presentation and overlapping morphological features. Immunohistochemistry helps in overcoming diagnostic difficulties in problematic cases. Aims and Objectives: The aim of the study is to analyse histopathological spectrum of CNS tumours irrespective of age in a single institution. Materials and Method: A one year prospective study was carried out in department of pathology from 2016 to 2017, at the department of pathology, ASRAM. Neurosurgical specimens were formalin-fixed and paraffin-embedded and stained with Haematoxylin and eosin. Immunohistochemical markers were applied in selective cases like S-100, CD-45, etc. Results: In our study, seventy two (72) brain neoplasms were analysed. Neuroepithelial tumours (25) were most common, followed by meningothelial tumours (22), tumours of sellar origin(12), tumours of cranial and paraspinal nerves(5), metastatic tumours(4) and others (4). Conclusions: The present study highlights the histological diversity of CNS tumours in various age groups. CNS tumours peak incidence was noted at 4th to 5th decade. Meningiomas and astrocytomas were common tumours after 40 years of age. GBM was the most common among astrocytomas. Immunohistochemistry was helpful in dilemmatic cases.
International Journal of Scientific Reports, 2021
Background: Descriptive epidemiology of intracranial central nervous system (CNS) tumours is a significant part of tumour studies which provides information on magnitude and distribution of the lesions. The objective of this study is to provide an overview of frequency of intracranial CNS tumours with comparison with national and international data. Methods: In this retrospective study 101 intracranial CNS tumours diagnosed over a period of 4 years were included. Histological diagnosis of tumours was confirmed and they were classified according to revised WHO classification of CNS tumours 2016. Frequencies of tumours in accordance to age, gender, location, laterality and grades were evaluated. Results: Total 101 cases including 59 (58.42%) males and 42 (41.58%) females were studied. Paediatric and adult cases accounted for 17 (16.83%) and 84 (83.17%), respectively. Most tumours were noted in the 6th decade. Out of total cases, 91 (90.1%) were primary intracranial CNS tumours and 10 (9.9%) were metastatic tumours. Most common tumours were astrocytoma followed by meningioma. Among children, astrocytoma (41.18%), medulloblastomas (41.18%), ependymomas (11.76%) and meningiomas (5.88%) were the reported lesions. In adults, astrocytoma (39.29%), meningiomas (23.81%), metastatic tumours (11.90%), ependymomas (8.33%), hemangioblastomas (5.95%) and schwannomas (4.76%) were common. Glioblastomas were the commonest astrocytoma. WHO grade I tumours were commonest followed by grade IV. Conclusions: The study gives a glimpse of prevalence of intracranial central nervous system tumours forming a baseline profile based primarily on the histopathological diagnosis at rural tertiary care hospital.
Clinico-pathological study of central nervous system tumors
IP innovative publication pvt. ltd, 2019
Introduction: Central nervous system tumors show varied histomorphological spectrum although they are less frequent when compared to other sites. Central nervous system (CNS) tumors refer to neoplasms that originate in the brain and spinal cord of which over 90% are located in the brain. CNS malignancies account for approximately 1.7% of new cancers annually. Aims and Objectives: 1: To study the demography and determine the relative frequency of the various histopathological types of CNS tumors; 2: To relate the occurrence of the various types of CNS tumors with age, sex, signs, symptoms, location and to study the various spectrum of histopathological features of CNS tumors and grade according to WHO classification (2007). Results and Conclusion: The most frequent type of CNS tumor was meningioma followed by astrocytoma of which WHO grade IV tumor was frequent and schwannoma. The peak incidence was in 41-50 years age group. Overall Males are affected more than females, with male to female ratio of 1.2:1 except in meningioma where there is a female preponderance with male to female ratio of 1:2.1. The most frequent clinical feature was headache and seizures in supratentorial tumors of intracranial region, backache, weakness and sensory disturbances in spinal cord tumors. The most commonest site of occurrence was frontal lobe followed by multilobe involvement.
Characteristic of Central Nervous System Tumours from 2011-2015: A Single Institution Study
Medicinus
Background: Central nervous system (CNS) tumours affect the quality of life of patients since its neurological deficits. Data from Globocan 2012 reveals that there are 256,000 cases of CNS tumour. Epidemiology of the CNS tumours is very important for diagnosis and treatment, but data in Indonesia is still not fully reported.Objective: The aim of this study was to determine the exact amount of the incidence, histologic type of the tumour and the characteristic of patient in our institution.Methods: This is an observational study, all pathology report of CNS tumours that underwent surgery at Siloam Hospitals Lippo Village from 2011 until 2015. We classified based on gender, age, location of the tumour, and the histologic type according to WHO Classification of CNS tumour 2007.Results and Discussion: There were 913 patients of CNS tumours from 2011 until 2015. The most common tumours were meningioma (32.96%) followed by glioma (21.35%) and pituitary adenoma (16.10%). In meningioma, mos...
Histological pattern of central nervous system neoplasms
JPMA. The Journal of the Pakistan Medical Association, 2001
OBJECTIVE To see in a large series of patients the histological pattern of CNS neoplasms and to provide a comprehensive data about the frequency of CNS neoplasms in Pakistani patients and to give a clearer idea about their prevalence. METHOD Retrospective study of all consecutive cases of CNS neoplasms diagnosed at The Aga Khan University Hospital (AKUH) between 1st January, 1994 and 31st December, 1999. SETTING The section of Histopathology, AKUH, Karachi. OBSERVATION Our series included a large number of cases i.e., 1110. There are very few local studies on CNS tumours and none so large. Our data was correlated with published Western and Pakistani data. Glial tumours were the commonest primary CNS neoplasms followed by meningiomas. Among glial tumours, astrocytomas comprised the largest group and the majority were high grade (III and IV) astrocytomas. Percentages of anaplastic oligodendrogliomas and ependymomas were also significant. Male to female ratio was 1.6:1. However, mening...
Clinicopathological pattern of brain tumors: A 3‑year study in a tertiary care hospital in India
Background: Brain tumors are heterogeneous group of neoplasms, affecting different age groups. Although some studies have been published regarding pathological pattern of brain tumors from different countries of the world and also from India, comprehensive clinicopathological studies from Eastern India is lacking. Aims: The aim of this study was to observe recent incidence of different brain tumors and to study clinical and histopathological spectrum of brain tumors in Eastern India. Materials and Methods: The present study was a cross‑sectional observational study involving 130 cases of brain tumors which were diagnosed during the 3‑year study period (January 2010–December 2012). Data regarding clinical presentation and radiological features of all cases were collected from all patients. Histopathological diagnosis was correlated with clinical and radiological diagnosis. Results: We found 130 cases of brain tumor with a male preponderance. The cases were distributed in a wide age range from 4 years to 78 years with the mean age of 42.38 years. Most common tumor type in our study was neuroepithelial tumor (92 cases, 70.76%). Among the neuroepithelial tumors, most frequent subtype was astrocytic tumor (54 cases, 41.5%). The second most frequent brain tumor was meningioma (20 cases, 15.3%). We found higher incidence of oligodendroglial tumor (8.46%) and medulloblastoma (7.69%) in our series. Conclusion: Males are more predispose to brain tumors in comparison to females. Astrocytic tumors are most common subtype in Eastern India. However, the WHO Grade I neoplasms are more frequent brain tumors.