Influence of uremia and hemodialysis on circulating interleukin-1 and tumor necrosis factor alpha (original) (raw)

The study investigates the influence of uremia and hemodialysis (HD) on the levels of circulating interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFa). It examines how different dialysis membranes affect the release of these cytokines. Findings indicate that plasma IL-1 levels are significantly elevated in long-term HD patients, while TNFa levels show no significant change before and after dialysis, regardless of the membrane type used. This suggests that hemodialysis and uremia impact cytokine production differently, with implications for understanding immune function in dialysis patients.