Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver (original) (raw)

Control of Heme Oxygenase and Plasma Levels of Bilirubin by a Synthetic Heme Analogue, Tin-Protoporphyrin

Karl Anderson

Hepatology, 1984

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The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin

George Drummond

Proceedings of the National Academy of Sciences, 1985

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Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver

Mohinder Sardana

Journal of Clinical Investigation, 1985

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In vitro inhibition of heme oxygenase isoenzymes by metalloporphyrins

Ronald Wong

Journal of Perinatology, 2011

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Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation

George Drummond

Proceedings of the National Academy of Sciences, 1981

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Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism

Mohinder Sardana

Archives of Biochemistry and Biophysics, 1987

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Control of heme metabolism with synthetic metalloporphyrins

George Drummond

Journal of Clinical Investigation, 1986

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Properties of human kidney heme oxygenase: Inhibition by synthetic heme analogues and metalloporphyrins

Pavel Martasek

Biochemical and Biophysical Research Communications, 1988

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Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources

George Drummond

The Journal of experimental medicine, 1987

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Studies with the haeme oxygenase inhibitor Sn-protoporphyrin in patients with primary biliary cirrhosis and idiopathic haemochromatosis

Bo Angelin, Rolf Hultcrantz

Gut, 1990

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Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications

George Drummond

Journal of Clinical Investigation, 1985

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Systemic Effects of Orally-Administered Zinc and Tin (IV) Metalloporphyrins on Heme Oxygenase Expression in Mice

Christopher H Contag

Pediatric Research, 2006

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Retinoic Acid in Association with Tin-Metalloporphyrins Influences Heme Metabolism in vivo in Rats

Ramesh Prof Chandra

International Journal for Vitamin and Nutrition Research, 1999

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The Effect of Tin (IV)-Protoporphyrin-IX on Bilirubin Production and Excretion in the Rat

Lawrence Gartner

Pediatric Research, 1987

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Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production

George Drummond

Journal of Clinical Investigation, 1985

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Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male wistar rats

Ramesh Prof Chandra

European Journal of Drug Metabolism and Pharmacokinetics, 2003

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Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen

George Drummond

The Journal of experimental medicine, 1982

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Interaction of porphyrins with heme proteins – a brief review

Abhay Chakraborti

2003

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Effects of Metalloporphyrins on Heme Oxygenase-1 Transcription: Correlative Cell Culture Assays Guide In Vivo Imaging

Christopher H Contag

Molecular Imaging, 2003

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Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells

ed cable

Journal of Clinical Investigation, 1994

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Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes

Garry Buettner

AJP: Cell Physiology, 2006

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Effects of tin-protoporphyrin IX on blood flow in a rat tumor model

Gillian Tozer

Experimental biology and medicine (Maywood, N.J.), 2003

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The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin

Ronald Wong

Biochemical and Biophysical Research Communications, 2007

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Protoporphyrin IX: the good, the bad and the ugly

Karl Anderson

The Journal of pharmacology and experimental therapeutics, 2015

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Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: Evidence against a stress-mediated response

ed cable

Molecular and Cellular Biochemistry - MOL CELL BIOCHEM, 1997

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Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy

Monica Pibiri

Life Sciences, 2018

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Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury

maria detsika

International Journal of Molecular Sciences

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Control of heme and cytochrome P-450 metabolism by inorganic metals, organometals and synthetic metalloporphyrins

George Drummond

Environmental Health Perspectives, 1984

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In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor

Jun Fang, Teruo Akuta

Cancer research, 2003

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Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha)

George Drummond

The Journal of experimental medicine, 1985

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Metalloporphyrins—Applications and clinical significance

tech perfect

Indian Journal of Clinical Biochemistry, 2000

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Photodynamic effects of hematoporphyrin-derivative on enzyme activities of murine …

Tom Dubbelman

… of Photochemistry and …

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Fluorimetric study of the binding of protoporphyrin to haemopexin and albumin

Angelo Lamola

Biochemical Journal, 1981

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