The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis (original) (raw)

Liposarcoma of soft tissue: MRI findings with pathologic correlation

Skeletal radiology, 1997

Objective. To evaluate the MRI findings of liposarcomas of different histologic types and correlate these with the histopathologic features. Design. The MR images of seven liposarcomas were reviewed retrospectively to assess the tumor size, location, margination, signal characteristics and enhancement patterns in different histologic types. Patients. Seven liposarcomas comprising three well-differentiated, two myxoid and two pleomorphic types were evaluated. Results and conclusion. All tumors showed well-defined and mostly lobulated margins. The well-differentiated liposarcomas were composed mainly of fat with septations or nodules, were hyperintense on T2weighted images, and demonstrated faint enhancement or no enhancement following intravenous contrast. Myxoid liposarcomas were homogeneous or mildly heterogeneous and a pseudocapsule was present in one case. Pleomorphic types showed a markedly heterogeneous internal structure. Both myxoid and pleomorphic lesions-showed moderate or marked heterogeneous enhancement after contrast administration. Welldifferentiated liposarcomas may be differentiated from other types of the tumor by their largely lipomatous appearance. The malignancy grade increases in parallel with tumor heterogeneity and contrast enhancement.

Magnetic Resonance Imaging Assessment of Lipomatous Soft-tissue Tumors

In Vivo, 2017

Aim: To establish the accuracy of magnetic resonance imaging (MRI) in distinguishing between benign and malignant lipomatous tumors; to evaluate the reproducibility of the MRI interpretation assessing the agreement between judgments of two radiologists with the same experience in soft-tissue sarcomas; to identify an association among MRI findings (size, depth, septa, nodules, signal homogeneity) and nature of the lesion. Materials and Methods: A total of 54 patients (28 men and 26 women), with a mean age of 56 (range=27-84) were included years. All subjects followed-up by the Multidisciplinary Sarcoma Group. The following MRI findings were judged in a blind study by two radiologists: size, localization, septa, nodules and signal homogeneity. A diagnostic indication was then given from among lipoma, atypical lipomatous tumour (ALT) and liposarcoma. Accuracy in distinguishing between benign and malignant lesions, and between lipoma and ALT (Fisher's exact test), inter-operator agreement (Cohen's kappa), association of MRI findings and malignancy of the lesion (Fisher's exact test and odds ratio) were evaluated. Results: The inter-operator agreement was complete (100%). The agreement between diagnostic hypothesis and histological diagnosis was statistically significant (p<0.05). Among the radiological findings taken into account, only septa and signal homogeneity were significantly associated with the malignancy of the lesion (p<0.05). Conclusion: MRI could be helpful in distinguishing lipomatous tumors, allowing biopsy to be avoided in some cases (negative predictive value=100%). Adipocytic tumors are tumors of mesenchymal origin, which can be either benign (lipoma, lipomatosis, etc.) or malignant (liposarcomas). Liposarcomas are rare tumors of mesenchymal origin and are the second most common subgroup of softtissue sarcomas in adults, with a peak age of incidence between the fifth and seventh decade (10-35%) (1, 2). In 2013, the World Health Organization (WHO) Committee for classification of soft-tissue tumors revised the classification, dividing the category of liposarcomas into five histological subtypes: well-differentiated (or atypical lipomatous tumor), dedifferentiated, myxoid, pleomorphic and mixed. This classification is a precise differentiation of morphological and biological activity of the disease, with a behavior that can range from non-metastatic atypical lipomatous tumors (ALT) or well-differentiated liposarcomas (WDLS) to high-grade tumors such as pleomorphic liposarcomas, which have a real risk of developing distant metastases (3-5). The most common subtype in the liposarcoma family is ALT, which accounts for about 40-45% (5, 6), and arises, without sex predilection, most frequently in the sixth decade of life, and can potentially be located in any region, with slight prevalence in the deep soft tissues of the limbs, especially in the thigh. The term 'atypical lipomatous tumor' is usually preferred to cases where the neoplasia is localized in the limbs, and the definition 'well-differentiated liposarcoma' is preferably used for tumors localized in the retroperitoneum or in the mediastinum. Biologically, this tumor is a locally aggressive subtype, without metastatic potential, unless areas of 387 This article is freely accessible online.

Spectrum of liposarcomas-a study of 106 cases

Journal of Ayub Medical College, Abbottabad : JAMC

Liposarcoma is a malignant tumour that arises in fat cells in deep soft tissue. This study was conducted to access the spectrum of liposarcomas This descriptive study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi from 1st January 2008 to 31st December, 2012 and included all the cases diagnosed as liposarcomas. Records of the malignant tumors of soft tissue that presented during this period were analysed and out of this spectrum of liposarcomas were studied. A total of 19367 malignant tumours were diagnosed during study period. Out of these, 615 were malignant soft tissue tumours. Out of these 106 cases were liposarcoma with an overall frequency of 0.54% of the malignant neoplasm and 17.24% of soft tissue sarcomas .The age ranged from 26-85 years. Out of these 106 cases 77 were male and 29 were female with a male to female ratio of 2.6:1. The most common tumour seen was pleomorphic liposarcoma (42.5%) followed by myxoid liposarcoma (22.6%), dedifferentiated ...

Liposarcoma of the Back: Case Report

Surgical Science, 2019

Liposarcoma is a particular form of soft tissue sarcoma. First described by Virchow in 1860, liposarcoma is a rare mesenchymal tumor [1]. It represents 14% to 18% of all malignant tumors of the soft tissues and constitutes the most frequent soft tissue sarcoma [2]. For the majority of authors, it affects adult after the fourth decade. Because of the unusual age, we report a case of largeliposarcoma of the dorsal surface of the trunk. The appearance of the operative part made us think of a possible malignancy. A 35-year-old man without a notable patient history was admitted for a mass of the back discovered three years before without any notion of trauma. The patient affirms the recent appearance of an induration motivating the consultation. There were no associated signs such rectorrhagia, hematemesis, emaciation, pain. The physical examination finds a patient in good general condition. Locally, there is a swelling of the right lateral part of the 1/3 middle part of the back. It is an oval swelling of 25 cm long axis. Any fat tumor having a size more than 5 cm must therefore receive special attention even before the fourth decade.

Primary mediastinal liposarcoma: a case report

Journal of Medical Case Reports, 2007

Introduction: Liposarcoma is the most commonly diagnosed soft tissue sarcoma in adults and occurs predominantly in the lower limbs and retroperitoneum. Primary mediastinal liposarcomas are rare.

Patterns of recurrence in extremity liposarcoma

Cancer, 1999

BACKGROUND. Liposarcoma is one of the most common histologic types of soft tissue sarcoma and presents a wide spectrum of clinical behavior. The authors examined the correlation among histologic subtypes, outcomes, and patterns of recurrence among patients with extremity liposarcomas.

Rare primary Mediastinal Liposarcoma - A Case Report

Pakistan Journal of Chest medicine, 2017

Introduction: Liposarcoma is a malignant tumor of adipocytes and a commonly diagnosed soft tissue tumor in adults. It occurs in the limbs and retroperitoneum . Primary mediastinal liposarcoma is a rare entity, and very few cases have been reported. The presenting symptoms are related to invasion or compression of the adjacent structures. Case presentation: A case of 55 years old male, who presented to us with respiratory complaints due to huge primary mediastinal liposarcoma, was treated successfully with surgical excision. Postoperative period was uneventful. Conclusion: Surgical excision of mediastinal liposarcoma is the optimal treatment.

Liposarcoma: A Pictorial and Literature Review

Journal of clinical research in radiology, 2018

According to some clinical trials and epidemiologic studies, WDL is the most common LS (40%), followed by myxoid LS (20%), DDLS, pleomorphic LS (5%), and, last, mixed-type LS. [3,6,8] There are crucial differences among each subtype regarding presentation, treatment, and prognosis. WDL WDL is the most common subtype, representing the 40-50% of all LSs. WDL is a low-grade tumor due to their highly lipomatous content. Histologically, they are composed of variable size mature adipocytes, with scattered lipoblast and large fibrous stroma, and in some cases, they may present sclerosing and inflammatory components.