DNA methylation as a potential mediator between environmental pollutants and osteoporosis; a current hypothesis (original) (raw)
Osteoporosis, a prevalent silent disease characterized by low bone mass and increased fracture risk, may be influenced by environmental pollutants through mechanisms involving DNA methylation. Evidence suggests that exposure to pollutants such as heavy metals and particulate matter correlates with lower bone density. This paper posits that DNA methylation could mediate the effects of these pollutants on osteoporosis, highlighting the need for further experimental and epidemiological studies to explore this relationship and the biological mechanisms involved.