Impact of viral mutation on suppression of infection by cytotoxic T lymphocytes (original) (raw)

Abstract

ABSTRACT We develop a deterministic model describing the dynamics of infected cells wearing nnn epitopes recognizable by nnn CTL clones, in which mutation can lead to the epitopes becoming unrecognizable by their cognate CTL clone. Some mathematical and computational analyses of the resulting large scale system of 2n+n2^n+n2n+n equations are conducted. The model is used to examine the ability of CTL response to suppress infection in the presence of mutations. Several situations in which CTL escape happens are identified and conditions in which infection is controlled are also derived. The influence of the probability of mutation is numerically investigated.

Stephanie Portet hasn't uploaded this paper.

Let Stephanie know you want this paper to be uploaded.

Ask for this paper to be uploaded.