Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats (original) (raw)
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Hypericum perforatum is known to have diverse medicinal uses for centuries. The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder. Hypericum is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats. Hypericum was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days. Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats. Hypericum significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity. Taken together, Hypericum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.
Hypericum perforatum is known to have diverse medicinal uses for centuries. The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder. Hypericum is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats. Hypericum was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days. Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats. Hypericum significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity. Taken together, Hypericum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.
Journal of Pharmacy and Bioallied Sciences, 2012
Hypericum exist worldwide with a native geographical distribution including temperate and subtropical regions of North America, Europe, Asia, Russia, India, and China. The major active constituents are considered to be hyperforin, hypericin, pseudohypericin, flavonoids, and tannins. [1] Hypericum perforatum is best known for its effect on mildto-moderate depression. Investigations proved several pharmacological activities for Hypericum perforatum including antipyretic, analgesic, antispasmodic, antiviral, and antimicrobial activities as well as its role in treatment of
H. perforatum L. is widely used for the treatment of mild to moderate forms of depression. The aim of the present study is to compare the antidepressive effect of the H. perforatum to H. maculatum, the most widely spread species from Romania. The powdered aerial parts of vegetal product were extracted with ethanol 70°, minimum content in total hypericins for the medicinal drug were determined by a spectrophotometer method. The experiment was carried out on 15 female Swiss mice, divided in three equal groups, H. perforatum group, H. maculatum group and control. The both extracts were injected 30 minutes before the experiment, 70 mg DS/kg body weight. Forced Swimming Test (FST) was performed by using the classic Porsolt's method, with minor changes. Both extracts (H. perforatum and H. maculatum) increase the immobility time as compared to control, the difference were distinct statistically significant; so, unexpectedly Hypericum sp. alcoholic extracts provide similar sedative effect.
BENEFICIAL EFFECT OF HYPERICUM PERFORATUM ON DEPRESSION AND ANXIETY IN A TYPE 2 DIABETIC RAT MODEL
Recent studies have revealed diverse therapeutically interesting pharmacological properties of a standardized Hypericum perforatum extract (HpE) potentially useful for treatments of patients with metabolic and psychiatric disorders. Consequently, the presented experiments were designed to test usefulness of the extract for the treatment of comorbid conditions of mood disturbances and anxiety in diabetic rats. Type 2 diabetes mellitus was induced in overnight fasted rats by a single i.p. injection of streptozotocin (STZ; 65 mg/kg), 15 min after an i.p. injection of nicotinamide (120 mg/kg). HpE was administered orally (100 and 200 mg/kg b.w..) to diabetic animals for 14 days. Anxiolytic activity was evaluated using open-field exploration test (OFT) and elevated plus maze (EPM) test. Antidepressant activity was assessed using Porsoltís forced swim test (FST). Fasting blood glucose levels in different groups were analyzed on the 14 th day. Diabetic rats showed significant increase in anxiety in OFT and EPM compared to non diabetic normal control rats. Diabetic rats treated with HpE have shown significant anxiolytic activity in OFT and EPM test. In FST, immobility period of vehicle treated diabetic rats was significantly increased (p < 0.05) compared to normal control rats. Treatment with HpE significantly decreased (p < 0.001) immobility period compared to vehicle treated diabetic control rats. HpE treatment significantly reduced elevated blood glucose levels in diabetic rats. The presented observations strongly suggest that HpE could be suitable alternative therapeutic option for prevention, as well as treatment, of comorbidities caused by, or associated with, depression, anxiety and diabetes.
Recent studies have revealed diverse therapeutically interesting pharmacological properties of a standardized Hypericum perforatum extract (HpE) potentially useful for treatments of patients with metabolic and psychiatric disorders. Consequently, the presented experiments were designed to test usefulness of the extract for the treatment of comorbid conditions of mood disturbances and anxiety in diabetic rats. Type 2 diabetes mellitus was induced in overnight fasted rats by a single i.p. injection of streptozotocin (STZ; 65 mg/kg), 15 min after an i.p. injection of nicotinamide (120 mg/kg). HpE was administered orally (100 and 200 mg/kg b.w..) to diabetic animals for 14 days. Anxiolytic activity was evaluated using open-field exploration test (OFT) and elevated plus maze (EPM) test. Antidepressant activity was assessed using Porsoltís forced swim test (FST). Fasting blood glucose levels in different groups were analyzed on the 14 th day. Diabetic rats showed significant increase in anxiety in OFT and EPM compared to non diabetic normal control rats. Diabetic rats treated with HpE have shown significant anxiolytic activity in OFT and EPM test. In FST, immobility period of vehicle treated diabetic rats was significantly increased (p < 0.05) compared to normal control rats. Treatment with HpE significantly decreased (p < 0.001) immobility period compared to vehicle treated diabetic control rats. HpE treatment significantly reduced elevated blood glucose levels in diabetic rats. The presented observations strongly suggest that HpE could be suitable alternative therapeutic option for prevention, as well as treatment, of comorbidities caused by, or associated with, depression, anxiety and diabetes.
Anti-diabetic activity of Indian Hypericum perforatum L. on alloxan-induced diabetic rats
2008
Anti-diabetic activity of the standardised extract of Indian Hypericum perforatum L. was investigated on alloxan induced diabetic rats. Indian Hypericum perforatum (IHp) extract was orally administered (100 and 200 mg/kg) as suspension in 0.3 % carboxy methyl cellulose for 14 days. Glibenclamide (10 mg/kg/day, p.o.) was used as standard. Blood samples were collected at day 0 and 14 th day (1 hour after last dose) from orbital sinus and blood glucose was estimated by commercially available kit. IHp treatment led to significant fall (p<0.01) in elevated blood glucose level. Moreover, IHp treatment also reverses the weight loss associated with alloxan treatment. The overall results indicate that IHp possess significant antidiabetic activity.
Hypericum perforatum extracts as potential antidepressants
Journal of Pharmacy and Pharmacology, 1998
Extracts of Hypericum perforatum have been used in the treatment of mild to moderate depression for many years in Europe. More recently, these extracts have become available in the USA as dietary supplements and have been popularly used to improve mood. In support of this practice, data from several controlled clinical studies suggest that Hypericum perforatum is better than placebo and as effective as established antidepressant drugs. These data have, however, several limitations that should temper our enthusiasm and argue for more research before accepting Hypericum perforatum extracts into our pharmacopoeia of established antidepressants. Extant data on the possible effects of Hypericum perforatum extracts in depression are here critically reviewed and plans for further research presented.