Multicellular tumor spheroids as in vitro models for studying tumor responses to anticancer therapies (original) (raw)

Animal Biotechnology, 2020

Abstract

Abstract This chapter highlights the rationale, potential, and implementation of multicellular tumor spheroids (MCTSs) in cancer research. MCTS is a three-dimensional in vitro model system that bridges the gap between two-dimensional monolayer cell cultures and an in vivo tumor tissue model system. Compared to monolayer cultures, MCTS resembles tumor tissue in terms of structural and functional properties and is suitable for studying metastasis, invasion, and therapeutic screening of drugs. Spheroid models are helpful in accelerating translational research in cancer biology and tissue engineering.

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