Yüksek rakımın alerjik rinit ve bronşiyal hiperreaktivite üzerindeki etkileri (original) (raw)
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Associations among high altitude, allergic rhinitis, and bronchial hyperreactivity
ENT Updates, 2017
Yüksek rak›m›n alerjik rinit ve bronfliyal hiperreaktivite üzerindeki etkileri Alerjik solunum hastal›klar› genel bir halk sa¤l›¤› sorunudur. Çeflitli tedavi seçeneklerine ra¤men baz› hastalar tatmin edici bir iyileflme elde edemez. Yüksek rak›m, bu hasta grubu için do¤al bir ilave ve/veya kurtarma tedavisi seçene¤i sunmaktad›r. Bu çal›flmam›zda, yüksek rak›m›n alerjik rinit ve bronfliyal hiperreaktivite üzerindeki etkilerini literatür eflli¤inde sunmay› amaçlad›k.
High-altitude treatment in atopic and nonatopic patients with severe asthma
European Respiratory Journal, 2012
The beneficial effects of high-altitude treatment in asthma have been attributed to allergen avoidance. Recent evidence shows that this treatment also improves airway inflammation in nonallergic patients. We hypothesised that high-altitude treatment is clinically equally effective in patients with severe refractory asthma, with or without allergic sensitisation.
Altitude healing effect in severe asthmatic children
Respiratory Medicine and Research, 2021
organized data collection, F. Faraj, S. Guibert and J. Léonardi performed medical evaluations, A. Loundoun performed the statistical analysis, J. Vitte performed immunologic analysis, D. Charpin set up the study, wrote and supervised the protocol and wrote the paper. All authors have approved the final article Financial support We thank CEMBREU (Centre européen médical bioclimatique de recherche et d'enseignement universitaire) and ARARD (Association régionale d'assistance respiratoire à domicile) for their financial support. The clinics contributed to the study by making their staff available.
The physiological impact of high altitude on nasal and lower airway parameters
European Archives of Oto-rhino-laryngology, 2011
The aim of this study was to investigate the impact of high altitude on nasal and lower airway parameters in a healthy population. This was a prospective study of 61 individuals who climbed to the summit of Mount Kackar, at 3,937 m. Peak nasal inspiratory flow rates were recorded in all participants at sea level and at the summit. In 32 participants who ascended to the summit, sea-level and summit peak expiratory flow rates and olfactory function were evaluated. A rise in altitude significantly decreased peak nasal inspiratory flow by a mean of 27.43%. Mean peak expiratory flow values measured at the summit were 8.94% lower than basal values. Between-value differences were statistically significant (p < 0.001, p < 0.05). At high altitude, there was a significant decrease in olfactory function, as determined by a significant reduction in smell detection (p < 0.05) and smell identification (p < 0.05). The effect of high altitude on nasal function was found to parallel that of the effect on lower airway function, together accounting for an adverse effect on airway flow rates. The nasal mucosa responded to high altitude with an increase in airway resistance and a consequent impaired sense of smell.
Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, 2001
Background Some patients with severe asthma cannot be controlled with high doses of inhaled steroids (ICS), which may be related to ongoing environmental allergen exposure. Objective We investigated whether 10 weeks of high altitude allergen avoidance leads to sustained benefits regarding clinical and inflammatory markers of disease control in adolescents with persistent asthma despite treatment with high dose ICS. Methods Eighteen atopic asthmatic adolescents (12±18 yr, 500±2000 mg ICS daily) with established house dust mite allergy, participated in a parallel-group study. Quality of life (PAQL), lung function, bronchial hyperresponsiveness (BHR) to adenosine and histamine, induced sputum and urine samples were collected repeatedly from 10 patients during a 10-week admission period to the Swiss Alps (alt. 1560 m) and at 6 weeks after return to sea level. Results were compared with those in eight patients, studied in their home environment at sea level for a similar time period. Throughout the study, asthma medication remained unchanged in both groups. Results During admission to high altitude, PAQL, lung function, BHR to adenosine and histamine, and urinary levels of eosinophil protein X (U-EPX), leukotriene E 4 (U-LTE 4 ) and 9a11b prostaglandin F 2 (U-9a11b PGF 2 ) improved significantly (P , 0.05), with a similar tendency for sputum eosinophils (P , 0.07). Furthermore, the changes in PAQL and BHR to adenosine and histamine were greater in the altitude than in the control group (P , 0.05). At 6 weeks after renewed allergen exposure at sea level, the improvements in PAQL (P , 0.05), BHR to adenosine (P , 0.07) and histamine (P , 0.05), as well as U-EPX (P , 0.05) and U-LTE 4 (P , 0.05) were maintained. Conclusion A short period of high altitude allergen avoidance, on top of regular treatment with ICS and long-acting b 2 -agonists, results in improvement of asthma, as assessed by clinical and inflammatory markers of disease severity. These findings indicate that short-term, rigorous allergen avoidance can improve the long-term control of severe asthma over and above what can be achieved even by high doses of inhaled steroids.
Ear, nose, and throat effects of high altitude
European Archives of Oto-Rhino-Laryngology, 2010
High altitude changes human physiology and can result in illnesses such as acute mountain sickness, high-altitude cerebral edema, and high-altitude pulmonary edema. The physiological impacts of high-altitude illnesses occur secondary to extravasation of Xuid from the intravascular space into the extravascular space during a rapid ascent. Headache, hearing disturbances, vestibular disturbances, epistaxis, sleep apnea, coughing, respiratory tract infections, and nasal obstruction are main ear, nose, and throat complaints of individuals travelling to high altitude. These complaints can cause delays or cancelations in a person's climbing plans. In this article, we review the ear, nose, and throat eVects of high altitude based on the relevant literature.
Effect of moderately high altitude on the pattern of lung disease
Annals of Saudi medicine, 1994
In high altitude areas, inspired atmosphere oxygen decrease proportionally to the vertical distance from sea level. Population in these areas some adaptive mechanisms to cope with the relatively hypoxic environment. This study compares populations who live in highland areas (2500 meters above sea level) with those in lowland areas (close to sea level). No differences were observed in the prevalence or mortality rate of respiratory diseases between these two groups. It is concluded that even if adaptive mechanisms can be observed in dwellers of moderately high altitude (<3000 m above sea level), such altitude does not adversely affect the pattern of respiratory disease in these populations. However, partial pressure of oxygen (PaO2) tends to be lower in individuals of high altitude areas, leading to marked oxygen desaturation when such individuals encounter a significant respiratory illness. Physicians are advised to introduce early and effective therapeutic measures before such d...
New England Journal of Medicine, 2001
The aims of this article are to outline the physiology of high altitude, the treatment of altitude illness and to describe opportunities for further education in mountain medicine.
Altitude and bronchial asthma in south-western Saudi Arabia
Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ
Through a house-to-house survey, 1325 people aged 11+ years registered at 2 primary health care centres (1 at high altitude and 1 at sea level) in Asir region, Saudi Arabia, were interviewed and examined for weight, height and peak expiratory flow rate. The prevalence of bronchial asthma at sea level (19.5%) was significantly higher than at high altitude (6.9%). Illiteracy, low income, use of coal and wood for heating, having a mud or tent house, lack of electricity inside dwellings and presence of sheep were also significant risk factors for bronchial asthma. In multivariate logistic regression, only altitude was found to be significantly associated with bronchial asthma (adjusted odds ratio = 3.94).