Effect of dietary n-3 PUFA from microalgae on blood, liver, brain, kidney and heart lipids (original) (raw)
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Evaluation of Marine Microalga Diacronema vlkianum Biomass Fatty Acid Assimilation in Wistar Rats
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Diacronema vlkianum is a marine microalgae for which supposed health promoting effects have been claimed based on its phytochemical composition. The potential use of its biomass as health ingredient, including detox-shakes, and the lack of bioavailability studies were the main concerns. In order to evaluate the microalgae-biomass assimilation and its health-benefits, single-dose (CD1-mice) studies were followed by 66-days repeated-dose study in Wistar rats with the highest tested single-dose of microalgae equivalent to 101 mg/kg eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA). Microalgae-supplementation modulated EPA and docosapentaenoic acid enrichment at arachidonic acid content expenditure in erythrocytes and liver, while increasing EPA content of heart and adipose tissues of rats. Those fatty acid (FA) changes confirmed the D. vlkianum-biomass FA assimilation. The principal component analyses discriminated brain from other tissues, which formed two other groups (erythrocy...
OCL, 2015
Marine microalgae are photosynthetic microorganisms producing numerous bioactive molecules of interest for health and disease care such as lipids rich in omega-3 fatty acids -as eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3)-and carotenoids (e.g., β-carotene, fucoxanthin, astaxanthin). It has already been shown that these molecules, individually used, are benefic in the prevention of diseases such as those associated with the cardiovascular risks, but also in some carcinomas. When these molecules are combined, synergistic effects may be observed. Microalgae, as a dietary supplement, can be used to study these synergistic effects in animal models in which dyslipidemia can be induced by a nutrition treatment. Different marine microalgae of interest are studied in this context to determine their potential effect as an alternative source to marine omega-3 rich fish oils, actually widely used for human health. Actually, the pharmaceutical and nutrition industries are developing health research programs involving microalgae, trying to limit the dramatic reduction of fish stocks and the associated pollution in the marine environment. The aim of this review is threefold: (1) to present research on lipids, particularly long chain polyunsaturated fatty acids, as components of marine microalgae used as food supplements; (2) to present the health benefits of some microalgae or their extracts, in particular in the prevention of cardiovascular diseases and (3) to highlight the role of Odontella aurita, a marine microalga rich in EPA used as food supplement with the aim of preventing cardiovascular diseases.
The polyunsaturated fatty acids from microalgae as potential sources for health and disease
In the classification of the plant kingdom, the microalgae occupy a particular place from their geographical localization, their behavior with respect to the environmental constraints but also from their morphology, their physiology and their biochemistry. These various aspects make their cellular machineries very flexible and able to produce many organic molecules with various biological activities such as proteins, polysaccharides, pigments and lipids of interest. With regard to the lipids, microalgae are able to produce many varieties and great amounts of fatty acids, especially of polyunsaturated fatty acids, making them candidates of interest within the framework of the production and exploitation of lipids in various sectors of industry and health. These fatty acids present in the lipids produced by microalgae can be used alike manner as those resulting from marine sources of animal origin such as fish in the field from health. The aims of this chapter are to present the bioch...
Nutrients
Long-chain polyunsaturated fatty acids, n-3 series (n-3 LC-PUFA), are known for their preventive effects against cardiovascular disease. In an unfavourable economic and environmental context of fish oil production, marine microalgae could be an alternative source of n-3 LC-PUFA and are of interest for human nutrition. The aim of this study was to evaluate the effects of P. tricornutum, a microalga rich in eicosapentaenoic acid and used as a food supplement, on the metabolic disorders associated with metabolic syndrome and obesity development. Three male Wistar rat groups (n = 6) were submitted for eight weeks to a standard diet or high-fat diet (HF) with 10% fructose in drinking water, supplemented or not with 12% of P. tricornutum (HF-Phaeo). Supplementation led to n-3 LC-PUFA enrichment of lipids in the liver, plasma and erythrocytes. Plasma transaminases showed no difference between the HF and HF-Phaeo groups. Body weight, fat mass, inflammatory markers and insulinemia decreased ...
Molecules
Long-chain polyunsaturated fatty acids n-3 series (n-3 LC-PUFAs), especially eicosapentaenoic and docosahexaenoic acids, are known to exert preventive effects on obesity and metabolic syndrome. Mainly consumed in the form of fish oil, LC-PUFAs n-3 are also found in significant quantities in other sources such as certain microalgae. The aim of this study was to evaluate the effects of Diacronema lutheri (Dia), a microalga rich in n-3 LC-PUFAs, on metabolic disorders associated with obesity. Three groups of male Wistar rats (n = 6 per group) were submitted for eight weeks to a standard diet or high-fat and high-fructose diet (HF), supplemented or not with 12% of Dia (HF-Dia). Compared to HF rats, HF-Dia rats showed a 41% decrease in plasma triacylglycerol (TAG) and an increase in plasma cholesterol (+35%) as well as in high-density lipoprotein cholesterol (+51%) without change to low-density lipoprotein cholesterol levels. Although fasting glycemia did not change, glucose and insulin ...
Microalgae as an alternative source of omega-3 long chain polyunsaturated fatty acids
2012
The health benefits of omega-3 long chain polyunsaturated fatty acids (omega-3 LC-PUFA) are recognized worldwide. The traditional source of omega-3 LC-PUFA is fish. However, global consumer needs cannot be supplied by the current global fish harvest. Therefore, new sources of omega-3 LC-PUFA have to be found. Microalgae are producers of omega-3 LC-PUFA and a potential alternative for seafood. Other sources of omega-3 LC-PUFA include krill oil, calamari oil and genetically engineered land plant crops.
Health promoting functional lipids from microalgae pool: A review
Algal Research, 2020
Current market trend and consumer's growing demand for healthy natural products have strengthened microalgae as an emerging source of nutrient rich natural food supplement. The constituents of food play a critical role in evolution of non-communicable disease and malnutrition. In this regard, microalgae based food products own positive health impacts and combating effects on non-communicable disease and malnutrition. These products appear as favourable sources of vitamins, minerals, proteins, functional lipids/poly unsaturated fatty acids and carotenoids etc. Present study highlights microalgae based poly unsaturated fatty acids such as omega-3 i.e. alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid and omega-6 and its biosynthesis, production, applications in public health and economic analysis associated with its production. Poly unsaturated fatty acids are considered as one of the promising sources of human's diet and their optimal proportion (omega-3 to omega-6; 1:1 to 1:4) is essential for prevention of non-communicable disease and other chronic diseases. Microalgae based poly unsaturated fatty acids functions as an alternative to fish oil and possess number of benefits in terms of taste, no/reduced toxins accumulation and veganism nature over animal based oils. Moreover, microalgae produce higher amount of omega-3 in contrast to animal based oils, for instance; Isochrysis galbana and Phaeodactylum tricornutum produce closely ≥2 folds higher eicosapentaenoic acid and Crytthecodinium cohnii produce nearly ≥6 folds higher docosahexaenoic acid than cod liver oil. In contrast, terrestrial plant-based poly unsaturated fatty acids lack eicosapentaenoic acid/docosahexaenoic acid. Thus, microalgae based poly unsaturated fatty acids represent compatible market for production of food and feeds products over fish and plant based poly unsaturated fatty acids. Current review provides critical examination of the literature investigating application of microalgae based functional lipids as dietary and nutraceutical supplement to improve public health. In addition, process economics and challenges have also been discussed in this paper.
Microalgae as source of polyunsaturated fatty acids for aquaculture
2005
The therapeutic significance of polyunsaturated fatty acid (PUFA) especially docosahexaenic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA) has been demonstrated by recent clinical and epidemiological studies. Fish oils are the major commercial source of long chained ω3 PUFA. Global production of farmed fish and shell fish has more than doubled in the past two decades, trends toward intensification and greater control over nutritional input resulting in increased demand for wild fish for feed. Feed is the largest production cost for commercial aquaculture (e.g. most farming of salmon, other marine finfish, and shrimp), and thus improving feed efficiency in industrial systems is already a priority. Moreover, fishmeal prices have risen in real terms in the past three decades and are likely to increase further with continued growth in demand. The possible decline of commercial fish stocks calls for research in alternative sources of PUFA. Considerable evidence has indicated that ω3 fatty acids in fish oils actually derive from zooplankton that consumes algae. Further the microalgae may have superior lipid stability compared to traditional PUFA because they are naturally rich in antioxidant carotenoids and vitamins and because lipids are microencapsulated by the algae cell wall.
Journal of Applied Phycology, 1993
Three species of microalgae were grown in mass culture to investigate the influence of culture technique and growth phase on the production of 20:5(n-3) and 22:6(n-3). These polyunsaturated fatty acids (PUFA) are considered to be essential in many marine animals diets for high growth and survival rates. The species of microalgae examined were Nannochloropsis oculata, Pavlova lutheri and Isochrysis sp. (clone T.Iso). All batch cultures (logarithmic and stationary phase) and semi-continuous cultures (logarithmic phase) examined contained high levels of the long-chain (n-3) PUFA, but production could be maximised by harvesting at specific times and growth phases. Maximum cellular content (pg cell -) of long-chain PUFA was found in logarithmic phase batch cultures of N. oculata and in stationary phase cultures of P. lutheri. The cellular content of PUFA in cultures of Isochrysis sp. did not change significantly with culture technique or growth phase. Alternatively, stationary phase cultures of all three species showed increased proportions (%) and cellular contents of triacylglycerols, and saturated and monounsaturated fatty acids with correspondingly decreased proportions of polar lipids and most PUFA relative to logarithmic phase cultures. The exception was the proportion and cellular content of 22:6(n-3) in P. lutheri which increased with triacylglycerol content. The mass of long-chain (n-3) PUFA per volume of culture was significantly higher in stationary phase cultures due to the higher cell counts per volume. These findings indicate that the opportunity exists to maximise PUFA production by microalgae with the potential to improve animal growth and reduce production costs in mariculture operations and may be of use in the large scale culture and harvesting of microalgae for the biotechnology industry.