Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial (original) (raw)

2018, International Journal of Epidemiology

AI-generated Abstract

The PREDIMED-Plus randomized trial builds on previous research demonstrating the efficacy of the Mediterranean diet (MedDiet) in reducing cardiovascular disease (CVD). It aims to investigate the impact of additional lifestyle interventions, such as physical activity promotion and energy reduction, on hard cardiovascular clinical events in overweight and obese adults. By integrating these lifestyle changes with the MedDiet, the trial hypothesizes that a more significant reduction in cardiovascular risk can be achieved compared to the MedDiet alone.

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