Epidermotropic CD8 positive lymphoproliferative diseases: histological and immunophenotypic similarities but markedly differing clinical behaviour (original) (raw)

Epidermotropic CD8 positive lymphoproliferative disorders exhibit significant histological and immunophenotypic overlap, yet they are characterized by markedly different clinical behaviors. This report details three distinct cases: lymphomatoid papulosis, aggressive epidermotropic cytotoxic T-cell lymphoma, and hypopigmented mycosis fungoides. Despite similar histopathological findings, these cases demonstrate a spectrum of clinical outcomes, ranging from indolent disease to rapid progression and mortality, underscoring the importance of clinical correlation in diagnosis and management.