Antibody Libraries from Immunized Repertoires (original) (raw)

Drug discovery series, 2005

Abstract

Polyclonal antibodies have been used from diverse species such as rabbit, goat, sheep, donkey, chicken, pigs, cats, dogs, minks, and cattle for almost a century as specific and highaffinity probes for a variety of immunological assays in research and clinical laboratories. While polyclonal-pooled immunoglobulin (Ig) is still the gold standard for the treatment of some human diseases, the high purity and specificity of monoclonal antibody will eventually oust these serum preparations from this position; monoclonal antibodies (MAbs) promise to be safer and more specific in therapy. While there

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