Eosinophilic Pustular Folliculitis of Infancy (original) (raw)
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Eosinophilic pustular folliculitis of infancy: A series of 15 cases and review of the literature
Journal of the American Academy of Dermatology, 2013
Background: Eosinophilic pustular folliculitis (EPF) of infancy is characterized by the presence of pustular lesions containing eosinophils. It is the least well-characterized of the EPF diseases. Objectives: We sought to define the clinical and histopathologic features of the condition. Methods: We conducted a retrospective review of the clinical data and histologic findings of 15 patients given the diagnosis of EPF of infancy at the Hospital Niño Jes us, Madrid, Spain, from 1995 to 2011, and of patient data published in MEDLINE with such a diagnosis from the disease description (1984-2011). Results: A total of 61 cases were collected. The disease was more common in males than females (ratio 4:1), and presented before 14 months of life in 95% of cases (mean 6.1 months; median 5 months). All patients had recurrent outbreaks and scalp involvement, and 65% had lesions on areas of the body other than the scalp. Tissue eosinophilia was present in all cases; however, true follicular involvement was observed only in 62% of cases in which histologic study was available. More than 80% of the patients were cured by 3 years of age (mean 25.3 months; median 18 months). Topical steroids were effective in 90% of cases. Limitations: This was a retrospective study. Conclusions: EPF of infancy presents most often in the first 14 months of life and usually resolves by 3 years of age. All patients showed scalp involvement, tissue eosinophilia, and recurrent outbreaks. The condition does not require aggressive treatment, as it is benign and self-limiting.
Eosinophilic Pustular Folliculitis (Ofuji Disease) in Childhood: A Review of Four Cases
Pediatric Dermatology, 1991
Four children under 2 years of age were treated at our hospital in the last three years with a recurrent vesiculopustular eruption of the scalp, variably extending to the face and limbs. AH cases followed a cyclical pattern. Three of tbe cbjidren had a moderate response to topical steroids, and one went into remission after a two-month course of erythromycin. Ethnic origin may be an important predisposing factor. Histologically, all patients showed a moderate mixed inflammatory infiltrate witb numerous eosinophils centered around bair follicles. Peripheral wbite blood cell count showing leukocytosis with eosinopbilia was observed in tbose cases measured, but no consistent immunoiogic abnormalities could be identified.
Generalized Eosinophilic Pustular Folliculitis of Infancy Responding to Hydroxyzine
Annals of dermatology, 2015
We report a case of generalized eosinophilic pustular folliculitis of infancy (EPFI) involving the scalp, face, trunk, and both lower extremities that was treated with a topical corticosteroid and hydroxyzine. Interestingly, the lesions responded to hydroxyzine in a dose-dependent manner. A 3-month-old female infant presented with itchy erythematous papules and pustules on the face, trunk, and legs that had been present since birth (Fig. 1A∼C). We performed a routine blood test and skin biopsy on a pustule of the trunk. Laboratory tests showed eosinophilia (eosinophil count: 5.19×10
Eosinophilic pustular folliculitis: A sterile folliculitis of unknown cause?
Journal of The American Academy of Dermatology, 1994
Background: Eosinophilic pustular folliculitis (EPF) was initially definedas a sterile folliculitis of unknown cause. Becauseattempts to demonstrate bacterial organisms have been unsuccessful, and antibiotictherapy is usually ineffective, a bacterial infectionis not considered a plausible causative factor for this disease. Objective: Our purposewas to describefive patients with the clinical and histologic characteristics of EPF and to report the results of bacterial cultures. Methods: Biopsy specimens were examined and pustules were cultured. Results: In three of the five patients,Pseudomonas infectionof the hair follicle was the cause of the disease as proven by repeated cultures and the responseto specific therapy. Three patients had a systemic disorder known to cause immunologic alteration: AIDS in one and a myeloproliferative disorder in two. Conclusion: Although EPF was initially defined as a sterile folliculitis of unknown origin, three of our patientshad an identifiable and treatable cause. We believethat thesecaseswarrant the diagnosis of EPF.
Eosinophilic pustular folliculitis
Journal of American Academy of Dermatology, 1986
tinct clinicopathologic entity will result in the recognition of more cases, with consequent development of greater insight into its cause, pathogenesis, and treatment. The cause of eosinophilic pustular folliculitis is unknown, as is the role of the eosinophils in the pathogenesis of this disease. One can only speculate whether they are the primary effector cells or are merely attracted secondarily. In view of the known epithelial cytotoxicity of eosinophilic major basic protein, it is tempting to speculate a role for this substance in the epidermal and infundibular damage seen in eosinophilic pustular folliculitis. 12
Journal of Dermatology, 2007
Eosinophilic cellulitis is characterized clinically by an acute dermatitis resembling cellulitis with unknown etiology. Eosinophilic pustular folliculitis is also a rare inflammatory dermatosis characterized by recurrent crops of erythematous follicular papulopustules that coalesce to form annular plaques with unclear etiopathogenesis. We describe a 20-year-old white male who had vesiculobullous and plaque-like lesions on the hands and feet and was diagnosed with bullous eosinophilic cellulitis clinically and histologically without any etiological agents. Following therapy with oral corticosteroid and oral tetracycline capsules, the lesions disappeared. After a 2-month asymptomatic period, the patient developed pruritic follicular papules and pustules on the lower and upper extremities and upper back. Stool examination revealed Gierdia intestinalis eggs. The patient had complete clearance with treatment of ornidazol for 2 weeks and indomethacin for 2 months. This is the first report of bullous eosinophilic cellulitis coexisting with eosinophilic pustular folliculitis without eosinophilia in the English published work.