GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2 (original) (raw)

This study investigates the roles of G protein subunits GNAI1 and GNAI3 in colitis-associated tumorigenesis in mice, focusing on how these proteins modulate IL6 signaling and the expression of GNAI2. The findings reveal that GNAI1 and GNAI3 knock-out mice exhibit increased tumorigenesis correlating with changes in cytokine production and immune cell populations, particularly involving CD4+ dendritic cells and myeloid-derived suppressor cells. Furthermore, targeting IL6 signaling in these models significantly reduces tumor formation, indicating that modulation of GNAI signaling pathways could be a novel strategy for preventing or treating colitis-associated cancer in humans.