Biochemical Indices of Combined Measure of Serum Uric Acid and Beta Human Chorionic Gonadotropin (β hCG) Versus Serum Uric Acid alone as Prognostic Indicators of Pregnancy Outcome of Preeclampsia (original) (raw)
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Journal of Advances in Medicine and Medical Research
Background: Measurement of variety of biological, biochemical and biophysical markers in pregnancy implicated in the pathophysiology of preeclampsia have been proposed to predict its development. Aim: To evaluate the accuracy of combined measure of maternal serum uric acid level and quantitative serum beta hCG versus serum beta hCG alone as prognostic indicators of pregnancy outcome among preeclamptic patients at the Federal Medical Centre, Yenagoa. Methods: This is a hospital based prospective case control study by systematic sampling selection. The two groups comprised of 100 consecutive patients each, one with pre-eclampsia (study group) and the other without pre-eclampsia (control) admitted for management into the antenatal ward and labour ward over the seven-month period of the study. The values of their serum uric acid and beta hCG levels were evaluated on admission and followed up. Data entry and statistical analysis was done using statistical package for social science (wind...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: High levels of uric acid concentration over normal pregnant values have been reported previously in established preeclampsia, hence it was suggested to be a useful biochemical prognostic marker of the disease.Methods: This is a hospital based prospective case control study where 100 patients with preeclampsia were recruited consecutively as they were admitted. 100 non-pre-eclamptics were also recruited as control. The foetomaternal data, adverse perinatal outcomes, maternal serum uric acid levels as well as complications of preeclampsia were recorded into the protocol. Statistical analysis was done using SPSS 22.0. Level of significance was set at p<0.05.Results: The mean age in the study group was 28±6.7 years while in the control group it was 31±6.5 years. The difference in age was not statistically significant (p=0.53). The mean serum uric acid level was significantly higher amongst participants with preeclampsia than in those without preeclampsia (405.6±995 µmol/L...
Maternal serum uric acid concentration and pregnancy outcomes in women with pre-eclampsia/eclampsia
Objectives: To determine the relationship between maternal serum uric acid levels and fetal/neonatal complications in women with pre-eclampsia/eclampsia, and to establish a predictive threshold value. Methods: A diagnostic test and historical cohort study conducted by prospective cross-sectional data collection on pregnant women with pre-eclampsia/eclampsia at Hue University Hospital, Vietnam, between March 2015 and July 2017. Pre-eclampsia was diagnosed based on ACOG criteria. Serum uric acid levels were measured by enzymatic colorimetric testing using a Cobas c 501 analyzer (Roche Diagnostics, Mannheim, Germany). Fetal complications included intrauterine growth restriction, preterm delivery, fetal death, and neonatal death. Results: There were 205 women enrolled. Serum uric acid at a cutoff of 393 μmol/L is a good predictor of fetal/neonatal complications (AUC 0.752), with 64.4% sensitivity and 79.5% specificity. High uric acid level (≥393 μmol/L) resulted in increased risk of preterm birth (OR 6.367, 95% CI 3.009-13.084), low Apgar scores (OR 5.514, 95% CI 1.877-16.198), intrauterine growth restriction (OR 7.188, 95% CI 3.592-14.382), and neonatal death (OR 7.818, 95% CI 1.614-37.867). There was no relationship between uric acid level and fetal death (OR 1.803, 95% CI 0.355-9.168). Conclusions: Maternal serum uric acid concentration is a good predictor of fetal/neo-natal outcomes in women with pre-eclampsia/eclampsia.
Serum Uric Acid in Preeclampsia Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women
Objective: The objective of study was to find out serum uric acid level in normal and preeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology O u t p a t i e n t Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and 'p' value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.
Analysis of Serum Uric Acid Levels in Early Second Trimester as an Early Predictor for Preeclampsia
Journal of Evidence Based Medicine and Healthcare, 2017
BACKGROUND Hypertensive disorders complicate 5-10% of all pregnancies. Screening for these factors in the second trimester of pregnancy will help in early detection of hypertensive disorders of pregnancy, thus enabling. 1. Early identification of patients at risk of developing preeclampsia and eclampsia. 2. Prophylactic medication to prevent hypertension or to reduce its severity. 3. Proper antenatal care. The aim of the study is to study the accuracy of serum uric acid levels in early second trimester (14-20 weeks) as early predictor of preeclampsia. MATERIALS AND METHODS 100 pregnant normotensive women between 14-20 weeks gestation with singleton pregnancy irrespective of parity were selected randomly and serum levels of uric acid was estimated. Regular follow up of the cases was done till delivery. Number of cases developing preeclampsia was noted. Results were analysed statistically. RESULTS Out of the 100 patients enrolled in the study, 11 developed preeclampsia while rest 89 remained normotensive. Mean value of uric acid in preeclampsia cases was 6.28±0.86 mg/dL while that in normotensive cases was 3.42±0.94 mg/dL. This result was statistically significant. CONCLUSION Serum uric acid level at 14-20 weeks of gestation was significantly raised in the cases who developed preeclampsia as compared to those who remained normotensive. Hence, serum uric acid estimation at 14-20 weeks of gestation could be used as an effective parameter for predicting preeclampsia.
Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Hypertensive disorders of pregnancy affect 6-8% of all pregnancies and along-with haemorrhage and infection, they form a complex triad, contributing immensely to maternal morbidity and mortality. Although exact aetio-pathogenesis of pre-eclampsia is unknown, multiple factors have been implicated to have a role in it; the factors being abnormal placental implantation, endothelial dysfunction, maternal immunological tolerance, cardiovascular, genetic, nutritional and environmental factors. Increased uric acid concentration is one of the most pronounced clinical findings in preeclampsia. Hyperuricemia in preeclamptic women is primarily due to a reduction in glomerular filtration rate due to endothelial dysfunction. In this study we look to explore the relationship between elevated serum uric acid and the perinatal outcomes, especially the ability to predict adverse perinatal outcomes.Methods: This was a hospital based retrospective study, conducted in A J institute of medic...
A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA
Background: The present study concentrate to get significant association of serum uric acid levels with pre-eclampsia and PIH and also between serum uric acid and severity of disease. Material and Methods: 80 Patients diagnosed as having Pre-eclampsia and 80 controls with similar age group were studied after taking their consent. Blood samples were collected under aseptic precautions in plain vacutainer for serum uric acid estimations. Uric acid estimation was done by Uricase Peroxidase Method on Fully Automated Biochemistry Analyzer Miura 300. Results: The observed mean serum uric acid levels in preeclampsia was 7.52±0.77 mg/dl as compared to 3.70±0.94 mg/dl in controls. Conclusion: High serum uric acid levels could be a useful indicator of the maternal and fetal complication in hypertensive patients.
International Journal of Research in Medical Sciences
Background: Pre-eclampsia is a leading cause of fetomaternal and perinatal morbidity and mortality. The role of serum uric acid (SUA) in determining the complications of preeclampsia has been controversial. This study compared mean SUA levels between severe pre-eclamptics and normotensive women at term and ascertained its correlation with outcomes of preeclampsia; as well as determined if there is a threshold value of SUA level beyond which fetomaternal complications occur.Methods: A case-controlled study where 80 severe pre-eclamptics at term and 80 normotensive women matched for gestational age were recruited. Blood samples were collected from them for assay of SUA levels and they were followed till delivery. The fetomaternal outcomes and the corresponding SUA levels at diagnosis were documented and variables statistically analyzed. A receiver operating characteristic curve was used to determine the cut-off value of SUA beyond which adverse fetomateral complications are likely to ...