Pharmacokinetics of Bis-Pyridinium Mono-Aldoximes (original) (raw)

Pharmacokinetics of Two Chlorine-Substituted Bis-Pyridinium Mono-Aldoximes with Regenerating Effect on Butyrylcholinesterase

Huba Kalasz

Molecules, 2020

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Mini review on blood-brain barrier penetration of pyridinium aldoximes

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Dose-Dependent Tissue Distribution of K117, a Bis-pyridinium Aldoxime, in Rats

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The Toxicokinetics and Toxicodynamics of Organophosphonates versus the Pharmacokinetics and Pharmacodynamics of Oxime Antidotes: Biological Consequences

Victor Voicu

Basic & Clinical Pharmacology & Toxicology, 2010

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Mini review on blood-brain barrier penetration of pyridinium aldoximes 2014

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Pyridinium aldoxime analysis by HPLC: the method for studies on pharmacokinetics and stability

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New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications

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Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, 2005

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In vitro Evaluation of Aldoxime Interactions with Human Acetylcholinesterase

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Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds

Harald Mückter

Biochemical Pharmacology, 2006

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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

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Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure

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Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases

Anita Bosak

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Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

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Journal of Biological Chemistry, 2020

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A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning

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Acta biochimica Polonica, 2011

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Pyridinium Oximes as Cholinesterase Reactivators. Structure-Activity Relationship and Efficacy in the Treatment of Poisoning with Organophosphorus Compounds

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Current Medicinal Chemistry, 2009

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Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning

Gordana Mendaš

ACS Chemical Neuroscience, 2020

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Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Jiri Kassa

Drug design, development and therapy, 2018

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Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation

Milena Anđelković

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Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain

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Kinetics of Human Erythrocyte Acetylcholinesterase Inhibition by a Novel Derivative of Physostigmine: Phenserine

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Pharmacokinetic studies of cholinesterase inhibitors

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Acta Neurol Scand, 2009

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Pharmacokinetics and pharmacodynamics of some oximes and associated therapeutic consequences: a critical review

Victor Voicu

Journal of Applied Toxicology, 2010

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