Clinical Features of Normal Weight Japanese Patients with Type 2 Diabetes who had Formerly been Obese (original) (raw)
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QJM : monthly journal of the Association of Physicians, 2008
Measurement of body weight with body mass index (BMI) is often utilized to stratify cardiovascular disease (CVD) risk. To determine CVD risk profile and disease burden in subjects with type 2 diabetes mellitus (T2DM) across different categories of body weight as defined by BMI. Prospective observational study. CVD risk including metabolic syndrome (MetS) and prevalence of macrovascular complications were determined for each category of body weight as defined by the World Health Organisation (WHO) classification. A total of 390 subjects were included in this study of which 35.9% were non-obese (BMI <30 kg/m(2)). Although increasing obesity as defined by BMI was associated with higher prevalence of central abdominal obesity, hypertension and MetS (P < 0.05), dyslipidaemia and macrovascular complications were not significantly different across the various body weight categories (P = NS). Similar observation was seen in non-obese (BMI <30 kg/m(2)) and obese subjects (BMI >30...
2016
Background: Epicardial adipose tissue thickness has been considered to be a possible cardiovascular risk indicator in recent reports. Aim of this study was to evaluate the relationship of echocardiographic epicardial fat thickness (EFT) with carotid intima-media thickness (CIMT), in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: In this hospital based cross sectional observational study a total of 64 patients with T2DM (mean age 54.51±6.60 years and 75.0% male) and 76 age and sex-matched non-diabetic control (mean age 54.97±6.11years and 71.1% male) were evaluated. Echocardiographic EFT and ultrasonographic CIMT were measured in all subjects. Results: Patients with T2DM had significantly increased EFT and CIMT than those of the non-diabetic controls (6.15±0.99 mm versus 4.39±0.61 mm, P< 0.001 and 0.77±0.09 mm versus 0.51±0.05 mm, P< 0.001, respectively). EFT was correlated with CIMT (r = 0.724, P < 0.001), duration of diabetes (r = 0.723, P < 0.001...
Diabetes Care, 1997
OBJECTIVE The aim of this study was 1) to compare intimal-medial thickness (IMT) of the carotid artery in nondiabetic and NIDDM patients and 2) to evaluate the association of this early marker of atherosclerosis with several cardiovascular risk factors, including plasma insulin and insulin resistance. RESEARCH DESIGN AND METHODS A total of 58 nondiabetic and 56 NIDDM patients, randomly selected among those attending the outpatient Diabetes Clinic or the Clinic for Internal Medicine were examined. BMI, waist-to-hip ratio (WHR), blood pressure, glycohemoglobin (HbA1c), and fasting concentrations of plasma glucose, serum lipids (total and HDL cholesterol, triglycerides), and serum insulin were measured. Insulin resistance was assessed by computing glucose disappearance rate from plasma after intravenous insulin injection (Kitt). IMT of the carotid artery was measured by ultrasonography. RESULTS IMT was significantly higher in diabetic patients, and the difference remained highly signif...