Influence of IFN-alpha2b, TGFb1 and some chemotherapeutic agents on the proliferation of endothelial cells (original) (raw)
Experimental oncology
Abstract
Aim: to study in vitro the antiproliferative influence of interferon-α2b (²FN-α2b), transforming growth factor-β1 (TGF-β1), cys-platinum, cyclophosphamide, and paclitaxel on the of human microvascular endothelial cells for the development of approaches of the antiangiogenic therapy of malignancies. Methods: [3H]-methylthymidine incorporation into human microvascular endothelial derma-derived cells (HMVECd) treated with ²FN-a2b, TGF-b1, cysplatinum, cyclophosphamide, and paclitaxel have been studied. Results: studied cytokines and drugs inhibited proliferation of HMVECd cells at low concentrations (²FN-α2b — 50.0 and 100.0 IU/ml; TGF-β1 — 5.0 ng/ml; cysplatinum — 0.5 μg/ml; paclitaxel — 10.0 μg/ml; cyclophosphamide — 50.0 μg/ml). Conclusion: low concentrations of ²FN-α2b, ÒGF-β1, cysplatinum, cyclophosphamide, ànd paclitaxel inhibited proliferation of cultured endothelial cells, suggesting a possibility of low-dose antiangiogenic therapy in the long-term (“metronomic”) regimen.
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