Phenytoin dosage adjustment in Saudi epileptics: utilization of steady‐state pharmacokinetic parameters (original) (raw)

European Journal of Neurology, 1999

Abstract

We determined the Michaelis‐Menten parameters (Vmax and Km) in 271 Saudi epileptic patients having generalized tonicclonic seizures and who were treated with phenytoin (PHT) using high pressure liquid chromatography (HPLC). The patients comprised 150 (55.4%) males and 121 (44.6%) females, with a mean age of 31.7 years (SD = 18.5). The mean Vmax, for subjects less than 16 years of age was 10.35 mg/kg/day (SD = 0.73, range = 3.77‐17.01), while for those above 16 years, the mean value was 7.99 mg/kg/day (SD = 0.15, range = 3.68–15.95). The difference was statistically significant (P < 0.001). Vmax was positively correlated with weight (r= 0.953), but negative with age (r= 0.903). Km values ranged from 1.01‐20.87 mg/litre. The adult Km mean of 6.52 mg/l (SD = 0.24) was significantly higher than the mean of 4.79 mg/l (SD = 0.40) for pediatric patients (P < 0.01), but Km was correlated neither with age nor with weight. Our results showed no difference between the predicted and obser...

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