Infection by Cag A positive strains of Helicobacter pylori is associated with autoimmune thyroid disease in Iranian patients (original) (raw)
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World Journal of Gastroenterology, 2012
AIM: To investigate the correlation between autoimmune thyroid diseases (ATDs) and the prevalence of Cag-A positive strains of Helicobacter pylori (H. pylori) in stool samples. METHODS: Authors investigated 112 consecutive Caucasian patients (48 females and 4 males with Graves' disease and 54 females and 6 males with Hashimoto's thyroiditis HT), at their first diagnosis of ATDs. Authors tested for H. pylori in stool samples using an amplified enzyme immunoassay and Cag-A in serum samples using an enzyme-linked immunoassay method (ELISA). The results were analyzed using the two-sided Fisher's exact test and the respective odds ratio (OR) was calculated. RESULTS: A marked correlation was found between the presence of H. pylori (P ≤ 0.0001, OR 6.3) and, in particular, Cag-A positive strains (P ≤ 0.005, OR 5.3) in Graves' disease, but not in Hashimoto's thyroiditis, where authors found only a correlation with Cag-A strains (P ≤ 0.005, OR 8.73) but not when H. pylori was present. CONCLUSION: The marked correlation between H. pylori and Cag-A, found in ATDs, could be dependent on the different expression of adhesion molecules in the gastric mucosa.
Autoimmune Thyroid Diseases and Helicobacter Pylori
Open Journal of Thyroid Research
Background: Helicobacter pylori infection is worldwide diffused with up to 50% of incidence in the population of the developed countries and the most virulent strains carrying the cytotoxin-associated gene A antigens. Moreover, bacterial and viral antigens have been suspected to be able to mimic the antigenic profi le of the thyroid cell membrane suggesting an important role in the onset of the autoimmune diseases, such as Graves' disease and Hashimoto's thyroiditis. Aims: we reviewed the studies concerning the relationship between the bacterium and the autoimmune thyroid diseases such as Graves' and Hashimoto's disease. Conclusions: the signifi cative association between Helicobacter pylori and Graves' disease suggests a possible role of this bacterium in the onset and/or the maintenance of the autoimmune disease.
Autoimmune thyroiditis and Helicobacter pylori--is there a connection?
2006
OBJECTIVES In this study we examined the anti-Helicobacter pylori (anti-H. pylori) antibodies in patients with autoimmune thyroiditis, with and without different polyglandular involvement, and in healthy controls. MATERIAL & METHODS Patients with autoimmune thyroiditis (AT) were divided into three groups: Group A: 23 patients with isolated AT, Group B: 30 patients with AT as a part of polyglandular activation of autoimmunity, and Group C: 7 patients with AT as a part of autoimmune polyglandular syndrome type II. Thirty healthy individuals served as controls (Group D). Anti-H. pylori antibodies were determined first by ELISA for classes IgG, IgA, and IgM, and subsequently by immunoblot for classes IgG and IgA. RESULTS ELISA: The number of patients with IgA antibodies in Group A (39%) and Group B (30%) differed significantly from controls (7%, p<0.05). Immunoblot: Anti-CagA antibodies were found in 13% of patients in Group A, 7% of Group B, 0% of Group C, and 20% of Group D. A high...
ORIGINAL REPORT The Association of Helicobacter pylori Infection with Hashimoto's Thyroiditis
2013
Autoimmune thyroid diseases (ATD) are multifactorial conditions that result from genetic predisposition in combination with environmental risk factors. Helicobacter pylori infection as an environmental risk factor has been proposed to imitate the antigenic components of the thyroid cell membrane and may play a leading role in the onset of the autoimmune diseases, such as Hashimoto thyroiditis. The aim of this study was to investigate the association between Helicobacter pylori (HP) infection and Hashimoto's thyroiditis (HT). The participants in this case-control study included 43 patients affected by Hashimoto's thyroiditis, and 40 healthy individuals without history of autoimmune disease as the control group. Anti HP IgG and anti-TPO antibodies were determined using ELISA method. Results were considered positive when the IgG anti-HP value was higher than 30 IU/ml and the anti-TPO autoantibody value was higher than 75 IU/ml. The mean TSH level was 18.3±16.8 IU/ml for patient...
Relationship between H. Pylori Patients and Autoimmune Thyroid Disease
Indian Journal of Forensic Medicine & Toxicology, 2020
Autoimmune Thyroid Disease (AITD) Autoimmune Thyroid Disease is one of the diseases, more common in women than men, caused by a combination of reasons discussed later. In this study, we have tried to understand how Autoimmune Thyroid Disease is related to H. pylori or Helicobacter Pylori. We have discussed the pathology and the manner in which AITD is developed This report depicts the relationship between Helicobacter pylori (H. pylori) and Autoimmune Thyroid Disease or Autoimmune Thyroiditis. However, some other reports concerning the relationship between H. pylori infection and Autoimmune Thyroiditis are conflicting. We've discussed how AITD is developed, along with the causes and effects of the disease. In this study, we've also aimed at determining the presence of H. pylori bacteria in AITD patients, particularly in Hashimoto's Thyroiditis and Grave's disease two of the commonly occurring thyroid diseases. The manner in which AITD develops is multi-factorial and H. pylori infection is reported more in AITD patients (adults). H. pylori is said to be involved usually in nongastrointestinal conditions.
The Egyptian Journal of Hospital Medicine, 2011
Autoimmune hypothyroidism commonly affecting females is one of the commonest causes of thyroid disease in adults. Among the various autoantibody tests applied in research and clinical practice, the determination of thyroid microsomal antibodies (TPO) and thyroglobulin antibodies (TG Ab) still retains its strong value in the screening for thyroid autoimmunity. Helicobacter pylori (H. pylori) infection plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, MALT (Mucosa Associated lymphocyte T) Lymphoma and gastric cancer.
Correlation between thyroid disorders and rate of Helicobacter Pylori infection
2019
Background : Hyperthyroidism and hypothyroidism are common thyroid disorders. Thyroid hormones have a great role in regulating mucosal cells and the growth of the gastrointestinal tract. In this study, we investigated the presence of Helicobacter pylori ( H. pylori) infection in various types of thyroid disorders. Materials and Methods: Our study included 297 patients whose thyroid status was identified by evaluation of thyroid hormones; triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) using Roche Electrochemiluminescence (ECL). H. pylori antibodies and antigen were evaluated by enzyme-linked immunosorbent assay (ELISA) kits in all cases. Results: Hypothyroidism had a significant correlation with H. pylori infection ( p <0.001). Hyperthyroidism was not related to H. pylori infection ( p =0.171). Also, in hypothyroidism, female sex more than male sex had a significant correlation with H. pylori infection ( p = 0.004). Conclusion: Decreasing thyroid horm...
Helicobacter pylori infection and autoimmune pathogenesis of gastric neoplasias
Gut, 2000
Aim: To verify a possible association between overall H. pylori and CagA+ H. pylori infection and autoimmune thyroid diseases (AITDs). Methods: Consecutive patients with AITDs admitted to one single centre of Endocrinology during one solar year were examined. The diagnoses were Hashimoto thyroiditis (HT) in 76, Graves' Disease (GD) in 39, and aspecific thyroiditis (AT) in 44 patients. Controls were 136 individuals without AITDs. Median values of fT3, fT4, anti-thyreoglobulin (Tg) antibodies, IL-1β, IL-6, and TNF-α in patients were compared with those in controls. H. pylori infection and CagA status were determined serologically. Structural homology of some thyroid proteins with H. pylori antigens was investigated. Results: H. pylori infection prevalence was significantly increased in GD (66.6%) and HT (64.4%) patients, vs. 29.4% of controls and 34.0% of AT. CagA seropositivity was significantly more frequent in GD (46.1%) and HT (46.9%) infected patients, vs. infected controls (20%). fT3 and fT4 median values were significantly decreased in infected CagA+ GD patients vs. uninfected GD patients. IL-1β median values were increased in patients respect to controls, independently of the clinical form of AITD. Median values of IL-6, TNF-α and anti-Tg autoantibodies in CagA infected patients were significantly higher than those measured in infected CagA− and uninfected patients and in infected CagA+ controls. The examined thyroid proteins shared putative conserved domains with numerous bacterial antigens. Conclusions: Overall H. pylori and CagA+ H. pylori infection were associated with GD and HT, putatively through an increased inflammatory status and molecular mimicry.
Background: Higher serological prevalence rates of helicobacter pylori (H. pylori) infection have been reported in patients with type 1 diabetes (T1DM) and autoimmune thyroiditis (AT). Patients with T1DM are at increased risk for developing other autoimmune diseases, most commonly AT. It is unknown whether H. pylori infection could explain the high prevalence of thyroid autoantibodies and AT in T1DM. The aim of the current study was to evaluate anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) autoantibodies in correlation with anti-H. pylori IgG and IgA in young patients with T1DM. Methods: Anti-H. Pylori IgG, IgA, anti-TPO and anti-Tg antibodies titers were measured in 162 euthyroid patients with T1DM and 80 healthy controls matched for age, sex and socioeconomic status.
Journal of Clinical …, 2006
Context and Objective: Pathogenesis of autoimmune thyroid disease (ATD) is multifactorial. Helicobacter pylori (Hp) infection has been proposed to be involved in nongastrointestinal conditions and reported more frequently in ATD adult patients. We evaluated the prevalence of Hp antibodies in young ATD patients and investigated the possibility that a susceptible immunogenetic profile could influence the development of ATD in subjects with Hp infection. Subjects and Methods: We retrospectively studied 90 children with ATD (median age 11.2 yr), 70 age-and sex-matched healthy subjects as controls, and 65 patients with Turner syndrome (median age 18.8 yr). Antibodies to Hp were determined at diagnosis in ATD patients and, in Turner patients, at the last control in cases without ATD and before the appearance of thyroid autoantibodies in the others. Serological and molecular human leukocyte antigen (HLA) typing for classes I and II polymorphisms was performed. Results: Prevalence of positive Hp serology resulted significantly higher in ATD patients than controls (P ϭ 0.032). No association was found between individual HLA alleles and Hp serology. HLA-A1, B8, and DRB1*0301 were found significantly associated with ATD. A significant interaction between HLA-DRB1*0301 and Hp infection was present in ATD patients and not controls (P ϭ 0.007), suggesting that the copresence of these two factors might favor ATD development. A similar phenomenon was observed in Turner syndrome patients (P ϭ 0.02; cumulative Mantel test, P ϭ 0.0001). Conclusions: Another target of Hp-elicited immune inflammatory response might be the thyroid gland in subjects with a peculiar immunogenetic profile so that ATD may be a consequence. Our findings suggest the opportunity of eradicating Hp infection in children with ATD and/or susceptible HLA alleles. (J Clin Endocrinol Metab 91: 176-179, 2006) Patients We retrospectively studied the following groups of patients. The first group consisted of 90 children with ATD (75 females and 15 males, median age at diagnosis 11.2 yr, range 1.1-21.8 yr). Sixty-five patients (52 females and 13 males, median age at diagnosis 11.1 yr, range 1.1-17.3 yr) had