Obstructive ileus of the large bowel is associated with low tissue levels of neuropeptides in the prestenotic bowel segment (original) (raw)

Gastroenterology, 1995

Abstract

The neuropeptides substance P, vasoactiveintestinal polypeptide, and the recently discoveredpeptide secretoneurin are neurotransmitters of theintrinsic nervous system of the gut and effect gutmotility. The aim of this study was to investigatewhether these neuropeptides are involved in thepathophysiology of large bowel ileus. Five patientsunderwent colonic resections for obstructive cancer ofthe colon. Full-thickness specimens of the resected colonwere taken 10 cm proximal and 10 cm distal to the siteof tumor obstruction. Substance P-, vasoactiveintestinal polypeptide-, and secretoneurin-likeimmunoreactivities were measured in the specimens byradioimmunoassay. In addition immunocytochemistry wasperformed. Tissue levels of substance P, vasoactiveintestinal polypeptide, and secretoneurin were lower inthe prestenotic than in the poststenotic bowel segment. Inaccordance, immunocytochemistry revealed a denserstaining of ganglion cells and fibers for all threeneuropeptides in the poststenotic bowel. The decreasedtissue levels of substance P, vasoactive intestinalpolypeptide, and secretoneurin in the prestenotic bowelsegment may contribute to the final decompensation ofobstructive ileus.

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