How autoreactive thymocytes differentiate into regulatory versus effector CD4 + T cells after avoiding clonal deletion (original) (raw)
Agonist Ligands Expressed by Thymic Epithelium Enhance Positive Selection of Regulatory T Lymphocytes from Precursors with a Normally Diverse TCR Repertoire
Joost Van Meerwijk, Paola Romagnoli
The Journal of Immunology, 2006
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Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR-repertoire 1
Joost Van Meerwijk
2006
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An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes
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Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery
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CD4+CD25+Foxp3+ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion
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The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development
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Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression
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Genetic control of thymic development of CD4+CD25+FoxP3+ regulatory T lymphocytes
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Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo
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Regulatory T cell development in the absence of functional Foxp3
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Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery
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Foxp3 + CD25 + regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
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Role of Cytokines in Thymus- Versus Peripherally Derived-Regulatory T Cell Differentiation and Function
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Foxp3-Deficient Regulatory T Cells Do Not Revert into Conventional Effector CD4+ T Cells but Constitute a Unique Cell Subset
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TCR Repertoire and Foxp3 Expression Define Functionally Distinct Subsets of CD4+ Regulatory T Cells
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CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells
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Shaping of the Autoreactive Regulatory T Cell Repertoire by Thymic Cortical Positive Selection
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