Inhibition of NF-?B activation in vitro and in vivo: Role of 26S proteasome (original) (raw)

Meth Enzymology, 1999

Abstract

The results observed with PS-273 have also been demonstrated with other boronic acid proteasome inhibitors, as well as the peptide aldehyde and lactacystin class of proteasome inhibitors. The relative potencies for inhibition in the above mentioned assays correlates generally with Ki values for proteasome inhibition. This is evidence that the intracellular mode of action of the inhibitors is indeed through proteasome inhibition.

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