A small dose of morphine increases intake of and preference for isotonic saline among rats (original) (raw)

A small dose oJ morphuze m~ reases tntal, e of and preJeren¢ e Jor tsotomc sahne among rats PHARMACOL BIOCHEM BEHAV 29(3) 617-623, 1988-Water-deprived rats were given hourly opportunities to ingest physiological sahne and water for a number of days until they were taking substantml amounts of both solutions Prior to some opportumtles to mgest, they were rejected with either morphine (2 0 mg/kg) or a placebo Across a variety of procedures, morphine increased retake of and. in 1-hr tests, increased preference for 0 ~/~ NaC1 Intake of 1 5% NaCI also increased after admlmstratlon of morphine These data suggest that endogenous oplolds are revolved in sodium retake These data also provide further support for the idea that one or more of the endogenous oplold systems are revolved In the regulation of ingestion Oplolds Salt retake Salt preference Morphine Endogenous oplolds