Programmed Cell Death and Senescence in Skeletal Muscle Stem Cells (original) (raw)

This research investigates the behavior of skeletal muscle stem cells (SMSc) concerning programmed cell death (PCD) and senescence, emphasizing the roles of growth factors IGF-II, FGF-1, and FGF-2. The study reveals that SMSc exhibit dependence on growth factor signals, with PCD being sensitive to both the type and concentration of growth factors, and suggests that an intricate balance between proliferation and death responses governs their growth dynamics. Furthermore, it highlights the need for careful control over culture conditions to accurately assess senescence in these cells.