Cobalt – trace element, nutritional supplement and regulator of hematopoiesis (original) (raw)

2016

Abstract

Cobalt (II) is a wide used metal as erythropoietic agent, nutritional supplement, in cosmetics, medical devices. The aim of the study was to evaluate the regulatory role of chronic treatment with cobalt compounds on mouse hematopoiesis. An in vivo experimental model for chronic exposure to cobalt chloride (CoCl2) and/or cobalt-EDTA (Co-EDTA) was established. Pregnant ICR mice were subjected to daily dose of 75 and/or 125 mg/kg body weight CoCl2x6H2O and/or Co-EDTA 2–3 days prior delivery. The compounds were dissolved in tap water. 25 pn newborn mice were separated into individual cages and treatment continued until day 90 pn. The animals were sacrificed on days 18, 25, 30, 45, 60 and 90. The control group consisted of age-matched mice obtaining tap water. Co(II) accumulation was analyzed in blood plasma and tissues. Whole blood was used for hematological analyses and histological studies were performed to evaluate the morphological changes. Results showed diverse effect of Co(II) co...

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