Role of MIF in Hepatic Inflammatory Diseases and Fibrosis (original) (raw)

Springer eBooks, 2017

Abstract

Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine/chemokine that is an important component of the innate immune response. Recent studies have identified multiple roles for MIF in the progression and resolution of different stages of inflammatory and fibrotic response to liver injury. Here we review the basic functions of MIF and its cognate and non-cognate receptors in hepatic injury and repair, with an emphasis on alcoholic and nonalcoholic liver disease. Specific functions of MIF and its receptors in hepatocytes, Kupffer cells (the resident macrophage in the liver), and hepatic stellate cells are discussed in the context of hepatocyte injury, inflammatory responses and fibrogenesis. Finally, we analyze the potential for MIF as a therapeutic target for hepatic inflammatory and fibrotic diseases.

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