Retinal nerve fiber layer thickness in chronic renal failure without diabetes mellitus (original) (raw)
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Study of retinal nerve fiber layer thickness in chronic kidney disease patients
Indian Journal of Clinical and Experimental Ophthalmology
To compare the RNFL thickness between CKD patients and age matched healthy controls and to correlate RNFL thickness with duration of CKD. RNFL thickness was also assessed in CKD patients with and without haemodialysis.: One hundred and fifty eyes were included in the study and were labeled as group A. Equal number of age matched controls were included in group B. RNFL thickness was measured using optical coherence tomography for optic nerve head (ONH) scan.Mean of average RNFL thickness was studied to be thinner in group A in comparison to group B. Statistically significant thinning was also noted in superior and inferior quadrant of group A. Increase in average RNFL thickness and increase in superior and temporal quadrant RNFL thickness was noted in HD group as compared to non- HD group. A negative correlation was noted between RNFL thickness and duration of CKD. : This study concluded that RNFL thickness was found to be thinner in CKD patients as compared to healthy individuals. H...
International Archives of Medicine, 2018
Purpose: To analyze the retinal nerve fiber layer thickness (RNFL) in CKD patients by means of optical coherence tomography, ascertaining mean overall RNFL and mean RNFL in the nasal, temporal, superior, and inferior quadrants and comparing these measurements to those obtained from a control group. Methods: This was a prospective, analytical, cross-sectional case-control study. The study sample comprised 22 eyes from 11 patients and 33 eyes from 17 patients in the case and control groups respectively. RNFLT was measured with a model 3000 OCT unit (Stratus OCT-3™, Carl Zeiss Meditec Inc., Dublin, CA). The fast RNFL protocol was used, which consists of three consecutive 3.4-mm-diameter circular scans centered on the optic nerve. Measured parameters included overall mean RNFL and mean RNFL at the temporal (316–45°), superior (46–135°), nasal (136–225°), and inferior (226–315°) quadrants. The Mann-Whitney U was employed to assess possible between-group differences in mean ...
Macular and Retinal Nerve Fiber Layer Thickness: Which Is More Helpful in the Diagnosis of Glaucoma?
Investigative Opthalmology & Visual Science, 2011
PURPOSE. To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS. Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating healthy from glaucomatous eyes was determined using 10 macular thickness and 16 cRNFL thickness parameters. Glaucomatous eyes were categorized into two groups using four criteria according to whether cRNFL thickness or macular thickness measurement was better for glaucoma detection (cRNFL better group [RBG], macula better group [MBG], respectively). The clinical characteristics were compared between RBG and MBG. ROC regression analysis was conducted to identify variables affecting diagnostic capability using either macular thickness or cRNFL thickness measurements. RESULTS. Four hundred twenty-four glaucomatous patients and 297 healthy subjects were analyzed. Of all cRNFL parameters, average thickness showed the largest AUC (0.958). Of macular parameters, the inferior outer sector showed the largest AUC (0.880). More eyes were placed into the RBG than the MBG, making use of all four criteria (90 vs. 24, 143 vs. 46, 76 vs. 18, and 103 vs. 36, respectively). RBG patients had a smaller optic disc area than did MBG patients in 3 of the 4 criteria. Signal strength affected the diagnostic performance of cRNFL thickness measurement (P ϭ 0.043), whereas that of macular thickness was not affected by any covariate analyzed. CONCLUSIONS. Overall, cRNFL thickness measurements were generally superior to those of macular thickness when used to diagnose glaucoma. Macular thickness parameters were of greater value in eyes with larger optic discs. (Invest Ophthal
RETINAL NERVE FIBER LAYER THICKNESS IN DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY
Transstellar Journal , 2019
Study aims to evaluate the retinal nerve fiber layer thickness in diabetic patients with and without retinopathy and to assess the correlation of retinal nerve fiber layer thickness among the cases diabetic retinopathy. A cross-sectional observational study was conducted at Department of Ophthalmology, PESIMSR, Kuppam during 2016–2019. Total 200 consecutive cataract known patients were selected based on SOP. Inclusion and exclusion criteria were employed to conduct the research work inclusion; all the patients with diabetes mellitus willing to give consent to clinical examination and evaluation. Exclusion; secondary glaucoma, patients who are mentally challenged, corneal and lenticular opacity, diabetic retinopathy with vitreous haemorrhage or retinal detachment and post retinal surgery. A total of 200 (400 eyes) cases were considered for the study group (G1:G2 = 100). Of which male comprises (61%) and females (39.0%), sex ratio 2:1. Diabetic status was recorded and it revealed that a total of 150 (75%) cases were subjected to diabetes and 50(25%) cases were subjected to non diabetes and it was found that the DM status is found to be statistically significant (p < 0.01). As per the findings, the average RNFL in the case of RE was 95.58 ± 6.96 in DM with DR and 98.08 ± 1.44 in DM without DR. It was found to be statistically significant (p < 0.01). In case of RNFL of LE was 95.80 ± 6.93 in DM with DR and 98.18 ± 1.48 in DM without DR, it was also found that there is a statistically significant (p < 0.001) with and without DR. The superior retinal nerve fibre layer thickness (p < 0.001), nasal retinal fiber layer thickness (p < 0.001), inferior retinal nerve layer thickness (p < 0.001), temporal nerve fibre layer thickness, macular thickness (p < 0.001), HBa1C (p < 0.001), serum creatine and serum cholestrol (p < 0.001) were found to be statistically significant. The present study concludes that the optical coherence tomography is an important non invasive tool for the assessment and quantification of the RNFL thickness in diabetes patients, while on evaluating for DR.
IP Innovative Publication Pvt. Ltd., 2017
Introduction: Diabetic retinopathy is one of the leading causes of blindness according to vision 2020 protocol. There is evidence of structural changes prior to clinically detectable vascular complications. With newer technologies, like optical coherence tomography (OCT) it is possible to obtain optical section biopsies and it aids in quantifying the effects of diabetic retinopathy on the retinal nerve fibre layer thickness. Objectives: To establish the role of OCT in evaluating the RNFL thickness in diabetics without clinically evident diabetic retinopathy. Materials and Methods: This study presents a total of 60 eyes of 60 patients attending the OPD at Bapuji hospital and Chigateri general hospital attached to J.J.M medical college, Davangere from September 2014 to September 2016. All patients were subjected to RNFL analysis using OCT. Results: In our study, we found a tendency towards thinning in RNFL thickness globally and significant RNFL thinning in the superior quadrant with increasing duration of diabetes (<5 years-120.24±17.54 and > 5 years-112.88±19.63). No significant change was observed with other variables. Conclusion: OCT may be used to detect earlier signs and structural changes of DR, leading to earlier diagnosis and intervention. The RNFL loss in diabetics without retinopathy could be an indicator of likely neuronal loss in early DR. Further clarifications are required in this regard, we believe that OCT measurements may be one of the useful methods to elucidate the characterization of early structural changes of DR.
Japanese Journal of Ophthalmology, 2013
Purpose To evaluate the capability of optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) measurements in glaucoma progression detection. Methods The study examined 62 eyes of 37 glaucoma patients observed over a 3-year period. All eyes underwent at least four serial RNFL measurements performed by Cirrus OCT, with the first and last measurements separated by at least 3 years. VF testing was performed by using the Swedish interactive threshold algorithm (SITA) Standard 30-2 program of the Humphrey field analyzer (HFA) on the same day as the RNFL imaging. Both serial RNFL thicknesses and VF progression were assessed by the guided progression analysis (GPA) software program. RNFL thickness progression was evaluated by event analysis. Total deviation (TD) in the superior or inferior hemifield was also examined. Results A total of 295 OCT scans and 295 VFs were analyzed. Five eyes exhibited progression by OCT only and 8 eyes exhibited progression by VF GPA only. When the analysis was based on the combined measurement findings, progression was noted in 6 eyes. The average of the progressive hemifield TD at baseline for combined RNFL and VF progression was-3.21 ± 1.38 dB, while it was-2.17 ± 1.14 dB for RNFL progression and-9.12 ± 3.75 dB for VF progression. The average of the progressive hemifield TD indicated a significant advancement of VF progression as compared to RNFL progression (P = 0.002). Conclusions When a mild VF defect is present, OCT RNFL thickness measurements are important in helping discern glaucoma progression.
Graefe's Archive for Clinical and Experimental Ophthalmology, 2010
Background To compare the peripapillary retinal nerve fiber layer (RNFL) thickness in eyes affected by nonarteritic ischemic optic neuropathy (NAION) or glaucoma as determined by optical coherence tomography (OCT). Methods This cross-sectional institutional study included 18 eyes with NAION (at least 6 months since the acute event) and 29 eyes with glaucoma, both having localized visual field (VF) defects confined to one hemifield. Twenty-nine normal subjects served as controls. The fast RNFL thickness protocol (3.4) of the Stratus OCT (Carl Zeiss Meditec, Dublin, CA, USA) was used. The RNFL thickness and inferior maximum/temporal average (Imax/ Tavg) and superior maximum/temporal average (Smax/ Tavg) data corresponding to the hemifield with and without visual sensitivity loss were compared between NAION and glaucomatous eyes and with corresponding quadrants in normal eyes. The area under the receiver operating characteristic curve (AUC), sensitivities, and specificities were used to determine the OCT parameters that differ most in the two groups. Results The mean RNFL thickness in the quadrants corresponding to the affected hemifield in the NAION and glaucomatous eyes was not significantly different (P>0.9), but the values for both were decreased compared to the control eyes (P<0.0001). The mean RNFL thickness in the quadrant corresponding to the unaffected hemifield was significantly lower in the glaucomatous eyes (73.8 ± 20.04 µ) than in the NAION eyes (96.6±23.32 µ, P= 0.023), and in both study groups compared to the controls (117.2±13.44 µ, P<0.0001 for glaucomatous vs control eyes, and P<0.025 for NAION vs control eyes). Smax/ Tavg and Imax/Tavg of the quadrant corresponding to the unaffected hemifield had the strongest power to differentiate the two diseases (an AUC of 0.92). Conclusions Stratus OCT detected significant quantitative differences in RNFL thickness between glaucomatous and NAION eyes, both conditions with hemifield defects. These differences might hold a clue in understanding the processes involved in optic nerve injury.