The type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells are trimeric proteins with collagenous triple helical domains comprising noncovalently associated monomers and Cys83-disulfide-linked dimers (original) (raw)

The study investigates the structural properties of type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells, revealing that these receptors function as trimeric proteins featuring collagenous triple helical domains. Using pulse/chase metabolic labeling and cross-linking experiments, the research confirms that the receptors are assembled from noncovalently associated monomers and Cys83-disulfide-linked dimers, exhibiting complex post-translational processing and oligomerization capabilities. Findings suggest that these receptors play significant roles in atherogenesis and other macrophage-associated physiological processes, underlining their broad ligand specificity and potential implications in immune responses.