Potential of Microalgae Extracts for Food and Feed Supplementation—A Promising Source of Antioxidant and Anti-Inflammatory Compounds (original) (raw)
Related papers
Food Chemistry, 2007
In order to identify new sources of safe and inexpensive antioxidants, the antioxidant capacity and total phenolic content of different fractions of 23 microalgae were evaluated, using Trolox equivalent antioxidant capacity assay and the Folin–Ciocalteu method, respectively. The microalgae were extracted using hexane, ethyl acetate and water by a three-step sequential extraction procedure. Most of these microalgae were evaluated for
Molecules
The functional food market has been in a state of constant expansion due to the increasing awareness of the impact of the diet on human health. In the search for new natural resources that could act as a functional ingredient for the food industry, microalgae represent a promising alternative, considering their high nutritional value and biosynthesis of numerous bioactive compounds with reported biological properties. In the present work, the phytochemical profile, antioxidant activity, and enzymatic inhibitory effect aiming at different metabolic disorders (Alzheimer’s disease, Type 2 diabetes, and obesity) were evaluated for the species Porphyridium purpureum, Chlorella vulgaris, Arthorspira platensis, and Nannochloropsis oculata. All the species presented bioactive diversity and important antioxidant activity, demonstrating the potential to be used as functional ingredients. Particularly, P. purpureum and N. oculata exhibited higher carotenoid and polyphenol content, which was re...
Biocatalysis and Agricultural Biotechnology, 2016
Antioxidant capacity and polyphenol content of both intra-and extracellular constituents were investigated in five naturally isolated microalgal strains using DPPH and Folin-Ciocalteu assays respectively. Three distinct solvents with different polarities including water, ethyl acetate and hexane were employed for extracting the bioactive compounds. Obtained data from DPPH assay suggest that the studied microalgal cells show significant levels of antioxidants and polyphenol compounds ranging from 14.68 ± 1.36 (Oocystis pusilla) to 68.68 ± 5.95 (Scenedesmus rubescens) µmol Trolox g −1 and 9.62 ± 1.37 (O. pusilla) to 48.57 ± 3.99 (S. rubescens) mg gallic acid equivalent (GAE) g −1 respectively. Considerable connection (R 2 =0.9316) between two investigated factors prove that a great part of antioxidant activity in the studied microalgae are due to its phenolic compounds. Besides, the results of growth kinetic studies and composition analysis in the most efficient strain (S. rubescens) showed a great potential for antioxidant and polyphenolic compounds production in large scales.
Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals
Applied Sciences
Microalgae are an untapped source of bioactive compounds with various biotechnological applications. Several species are industrially produced and commercialized for the feed or cosmetic industries, however, other applications in the functional food and pharmaceutical markets can be foreseen. In this study, nine industrial/commercial species were evaluated for in vitro antioxidant, calcium-chelating, anti-tumoral, and anti-inflammatory activities. The most promising extracts were fractionated yielding several promising fractions namely, of Tetraselmis striata CTP4 with anti-inflammatory activity (99.0 ± 0.8% reduction in TNF-α production in LPS stimulated human macrophages at 50 µg/mL), of Phaeodactylum Tricornutum with cytotoxicity towards cancerous cell lines (IC50 = 22.3 ± 1.8 μg/mL and 27.5 ± 1.6 μg/mL for THP-1 and HepG2, respectively) and of Porphyridium sp. and Skeletonema sp. with good chelating activity for iron, copper and calcium (IC50 = 0.047, 0.272, 0.0663 mg/mL and IC5...
Evaluation of the Antioxidant Activity of Cell Extracts from Microalgae
Marine Drugs, 2013
A growing market for novel antioxidants obtained from non-expensive sources justifies educated screening of microalgae for their potential antioxidant features. Characterization of the antioxidant profile of 18 species of cyanobacteria (prokaryotic microalgae) and 23 species of (eukaryotic) microalgae is accordingly reported in this paper. The total antioxidant capacity, accounted for by both water-and lipid-soluble antioxidants, was evaluated by the (radical cation) ABTS method. For complementary characterization of cell extracts, a deoxyribose assay was carried out, as well as a bacteriophage P22/Salmonella-mediated approach. The microalga Scenedesmus obliquus strain M2-1 exhibited the highest (p > 0.05) total antioxidant capacity (149 ± 47 AAU) of intracellular extracts. Its scavenger activity correlated well with its protective effects against DNA
Marine Drugs
The biochemical composition of three novel selected microalgae strains (Chlorophyta) was evaluated to confirm their potential possibilities as new sustainably produced biomass with nutritional, functional, and/or biomedical properties. Extracts from cultured Pseudopediastrum boryanum, Chloromonas cf. reticulata, and Chloroidium saccharophilum exhibited higher radical scavenging activity of DPPH (1,1-diphenyl-2-picrylhydrazyl) when compared to butylated hydroxytoluene (BHT), but lower than butylated hydroxyanisole (BHA). Total phenolic compounds and amino acids were determined by newly developed RP-HPLC methods. Total phenolic contents, as µg g−1 of dry biomass, reached 27.1 for C. cf. reticulata, 26.4 for P. boryanum, and 55.8 for C. saccharophilum. Percentages of total analysed amino acids were 24.3, 32.1, and 18.5% of dry biomass, respectively, presenting high values for essential amino acids reaching 54.1, 72.6, and 61.2%, respectively. Glutamic acid was the most abundant free am...
Microalgae, a Potential Natural Functional Food Source – a Review
Polish Journal of Food and Nutrition Sciences, 2017
Microalgae are a group of microorganisms used in aquaculture. The number of studies regarding their use as a functional food has recently increased due to their nutritional and bioactive compounds such as polysaccharides, fatty acids, bioactive peptides, and pigments. Specific microalgal glucans (polysaccharides) can activate the immune system or exert antioxidant and hypocholesterolemic effects. The importance of algal lipids is based on their polyunsaturated fatty acids, their anti-inflammatory effects, their modulation of lipid pathways, and their neuroprotective action. Microalgae peptides can bind or inhibit specific receptors in cardiovascular diseases and cancer, while carotenoids can act as potent antioxidants. The beneficial biological activity will depend on the specific microalga and its chemical constituents. Therefore, knowledge of the composition of microalgae would aid in identifying, selecting, and studying their functional effects.
Journal of Applied Phycology, 2019
The interest in using marine organisms as a source of novel bioactive compounds has increased recently, reinforcing the need to find efficient and cost-effective methods to extract these biocompounds. Thus, the present study has focused on evaluating four solvent systems and three extraction methods to obtain extracts of three macroalgae (Gracilaria sp., Fucus vesiculosus, and Ulva rigida) and two microalgae (Chlorella sp. and Nannochloropsis gaditana). The extracts were evaluated regarding yield, phenolic content, and potential antioxidant activity. Results showed that a lower organic solvent:water ratio increased macroalgae, but not microalgae, biomass extraction efficiency. Levels of total phenolics, ortho-diphenols and flavonoids were highly influenced by algae material and solvent system applied. Strong 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activity was obtained with ethanol:water, 80:20 (E80:20) microalgal extracts, while no visible trend was detected for macroalgae extracts. However, methanolic extracts were the most effective in scavenging of 2,2-diphenyl-1picrylhydrazyl (DPPH). In macroalgae, a high positive correlation was observed between phenolic content and antioxidant capacity while in microalgae, the opposite was verified, suggesting that in microalgae, phenolic compounds are not the main contributors to the observed antioxidant capacity.
Microalgae as a Potential Source of Bioactive Food Compounds
Current Research in Nutrition and Food Science Journal, 2021
Microalgae are unicellular, photosynthethic organisms that can grow on diverse aquatic habitatss like ponds, lakes, rivers, oceans, waste water and humid soils. Recently, microalgae are gaining importance as renewable sources of biologically active food compounds such as polysaccharides, proteins, essential fatty acids, biopigments such as chlorophylls, carotenoids, astaxanthin, as well as vitamins and minerals.The bioactive food compounds of microalgae enable them to be part of multitude of applications in numerous industrial products for healthy life and ecosystem. This review article summarizes the applications of biologically active food compounds derived from microalgae as nutraceuticals, healthy dietary supplements, pharmaceuticals and cosmetics. Further, this review article highlights the importance of research focus on the identification and extraction of bioactive food compounds from the huge numbers of microlage that exist in nature for sustainable global food security and...