The alleviative remedy effect of Dates’ fruit consumption on severity symptoms of Autism spectrum disorder: A randomized controlled three-month trial (original) (raw)
Related papers
Research Square (Research Square), 2023
Aim: This study aimed at evaluating the regular intake of palm dates fruit for 12 weeks in alleviating gastrointestinal (GI) severity symptoms among autistic Egyptian children aged 3-12 years and exploring predictors for non-responsiveness to its intake. Methodology: Participants were randomly assigned to receive one of three regimens with completed analysis as follows; 1st: 3 dates fruit/day (47 cases), 2nd: 5 dates fruit/day (42 cases), and 3rd: nondates group (42 cases). Responders were those who showed a reduction of GI symptoms from High-to Low-GI-Problems based on the GI Severity Index score (6-GSI) Results: There was an improvement in the GI severity symptoms with a signi cant reduction from the baseline of constipation and stool smell scores for the two dates fruit regimens than the non-dates group (p<0.001). 76.4 % of participants on the dates fruit regimens were responders versus 23.6 %. The study identi ed a de ciency of the baseline level of Lactobacilli and Bi dobacterium species' log, any pathogenic microorganisms in participants' stool, and those at inevitable risk of malnutrition as predictors for non-responsiveness to dates fruit intake. Conclusion: The current study con rmed the bene cial impact of dates fruit regular intake as a remedy for severe GI symptoms.
Dietary Approaches and Nutritional Complexities of Autism Spectrum Disorder
Dietary Approaches in Autism Spectrum Disorder, 2022
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by poor social interaction, repetitive behavior, learning difficulties, cognitive issues, and unusual eating patterns. Different factors including genetic and environmental variables have been identified to increase the risk of developing ASD. Objective: The main objective of the present review is to investigate the dietary approaches and modifications to reduce the intricacies related to ASD. Results: Studies included in this review suggested that abnormalities in the gut microbiota are involved in the pathogenesis and severity of the disease. Medical nutrition therapy for ASD consists of excluding harmful food components such as gluten, casein, processed foods, and excessive sugars and increasing the consumption of omega-3 fats, vitamins and minerals, probiotics, and antioxidants. Furthermore, awareness regarding food labels might help to avoid food allergens in diet. Conclusion: Active dietary treatments including the use of dietary supplements and elimination of processed foods appear to reduce the complexities of ASD. Furthermore, support of health care professionals and adopting public health approaches might help to prevent adverse outcomes related to ASD. Future research is required to determine the prevalence of ASD and related outcomes in low/middle income countries as this area is highly neglected.
Nutrients, 2018
This study involved a randomized, controlled, single-blind 12-month treatment study of a comprehensive nutritional and dietary intervention. Participants were 67 children and adults with autism spectrum disorder (ASD) ages 3-58 years from Arizona and 50 non-sibling neurotypical controls of similar age and gender. Treatment began with a special vitamin/mineral supplement, and additional treatments were added sequentially, including essential fatty acids, Epsom salt baths, carnitine, digestive enzymes, and a healthy gluten-free, casein-free, soy-free (HGCSF) diet. There was a significant improvement in nonverbal intellectual ability in the treatment group compared to the non-treatment group (+6.7 ± 11 IQ points vs. -0.6 ± 11 IQ points, = 0.009) based on a blinded clinical assessment. Based on semi-blinded assessment, the treatment group, compared to the non-treatment group, had significantly greater improvement in autism symptoms and developmental age. The treatment group had signific...
The Effects of Dietary Intervention on Children with Autism: A Case Study.
The purpose of this dissertation is to investigate the link between dietary interventions and children on the Autistic Spectrum. Through observational research and the completion of food diaries, the researcher looked at the types of foods consumed by a sample of children with autism both in a school and a home setting. Results of this research were compared against findings from a review of literature in the field of dietary and biomedical interventions. The prevalence of carbohydrate was a prominent finding in the research, with subsequent detrimental effects on children with autism discussed in regard to current research. The inclusion of a case study on a 5 year old boy with autism currently undergoing a dietary intervention provides a first-hand account of the possible benefits of such intervention. In his case, a gluten and lactose free diet coupled with nutritional supplement and organic produce has seen vast improvements on his behavioural, social and emotional development. Whilst the results of this case study highlight the positive impacts of dietary intervention on children with autism, further research is imperative to gain a greater understanding of this relationship as there is a lack of evidence in this field.
Journal of Personalized Medicine
Autism spectrum disorder (ASD) often involves a wide range of co-occurring medical conditions (“comorbidities”) and biochemical abnormalities such as oxidative stress and mitochondrial dysfunction. Nutritional supplements (“Nutraceuticals”) are often used to treat both core ASD symptoms and comorbidities, but some have not yet been formally evaluated in ASD. The potential biological mechanisms of nutraceuticals include correction of micronutrient deficiencies due to a poor diet and support for metabolic processes such as redox regulation, mitochondrial dysfunction and melatonin production. This paper reports on the results of the National Survey on Treatment Effectiveness for Autism, focusing on nutraceuticals. The Survey involved 1286 participants from across the United States. Participants rated the overall perceived benefits and adverse effects of each nutraceutical, and also indicated the specific symptoms changed and adverse effects. From these ratings the top-rated nutraceutic...
The role of probiotics in children with autism spectrum disorder: A prospective, open-label study
Nutritional neuroscience, 2017
There are limited data on the efficacy of probiotics in children with ASD, therefore, this study aims to evaluate the efficacy and tolerability of probiotics in an Egyptian cohort of children with ASD. Gastrointestinal (GI) flora were assessed by quantitative real-time PCR of stool samples of 30 autistic children from 5 to 9 years old. GI symptoms of autistic children were assessed with a modified six-item Gastrointestinal Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with Autism Treatment Evaluation Checklist (ATEC) before and after 3 months of supplementation of probiotics nutritional supplement formula (each gram contains 100 × 10(6) colony forming units of three probiotic strains; Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacteria longum). After probiotic supplementation, the stool PCR of autistic children showed increases in the colony counts of Bifidobacteria and Lactobacilli levels, with a significant reduction in their body weig...
Nutritional and Dietary Interventions of Autistic Spectrum Disorders: A Short Review
2019
Autism spectrum disorder (ASD) is a neurodevelopmental condition of heterogeneous etiology, categorized by social communication deficits, repetitive or restrictive behaviors and interests. Epidemiological studies display that the incidence of autism is increasing, and the treatment of autism is vitally important. Therefore, the purpose of this article is to reorganize evidence on the effectiveness of vitamins, minerals, essential Fatty Acid, and a Gluten-Free and Casein-Free (GFCF) diet as a treatment for children with ASD. The existing nutrition and dietary therapies have been lectured and their effects on ASD symptoms have been discussed briefly considering specific research. Reviewing the studies showed that nutritional and dietary therapies improved the core symptoms of ASD. This review article investigates the importance of vitamins, minerals, essential fatty acids and GFCF diet and the recent studies suggested that nutrition and dietary supplements may play an active role in ...
Report of a Meeting: Food, Nutrition, and Autism: From Soil to Fork
The American journal of clinical nutrition, 2024
Food and nutrition-related factors have the potential to impact development of autism spectrum disorder (ASD) and quality of life for people with ASD, but gaps in evidence exist. On 10 November 2022, Tufts University’s Friedman School of Nutrition Science and Policy and Food and Nutrition Innovation Institute hosted a 1-d meeting to explore the evidence and evidence gaps regarding the relationships of food and nutrition with ASD. This meeting report summarizes the presentations and deliberations from the meeting. Topics addressed included prenatal and child dietary intake, the microbiome, obesity, food-related environmental exposures, mechanisms and biological processes linking these factors and ASD, food-related social factors, and data sources for future research. Presentations highlighted evidence for protective associations with prenatal folic acid supplementation and ASD development, increases in risk of ASD with maternal gestational obesity, and the potential for exposure to environmental contaminants in foods and food packaging to influence ASD development. The importance of the maternal and child microbiome in ASD development or ASD-related behaviors in the child was reviewed, as was the role of discrimination in leading to disparities in environmental exposures and psychosocial factors that may influence ASD. The role of child diet and high prevalence of food selectivity in children with ASD and its association with adverse outcomes were also discussed. Priority evidence gaps identified by participants include further clarifying ASD development, including biomarkers and key mechanisms; interactions among psychosocial, social, and biological determinants; interventions addressing diet, supplementation, and the microbiome to prevent and improve quality of life for people with ASD; and mechanisms of action of diet-related factors associated with ASD. Participants developed research proposals to address the priority evidence gaps. The workshop findings serve as a foundation for future prioritization of scientific research to address evidence gaps related to food, nutrition, and ASD.
On The Effectiveness of Probiotic as Treatment Strategy of Autism
2018
The gut micro biota and its metabolites play important roles in the body physiology, including the brain. Dysbiosis or micro biota alterations are involved in numerous pathologies, including neuro developmental disorders. The frequent occurrence of gastrointestinal symptoms in autistic patients could suggest the possible involvement of impaired gut micro biota as etiological mechanism in autism. Up to our understanding of the etiological mechanisms of autism through our clinical and experimental research, it was interesting to relate altered gut micro biota to neuro inflammation, oxidative stress, heavy metal toxicity, autoimmunity, and glutamate excitotoxicity to clarify the possibility of targeting gut micro biota to ameliorate these contributed pathologic signaling and thus treat autism. The gut micro biota can indirectly affect the brain through the circulating pro-inflammatory and antiinflammatory cytokines or through the production of metabolites among which is short chain fat...
Journal of Clinical Medicine
Autism spectrum disorders (ASDs) represent a diagnostic challenge with a still partially uncertain etiology, in which genetic and environmental factors have now been assessed. Among the hypotheses underlying the involvement of biological and environmental factors, the gut–brain axis is of particular interest in autism spectrum disorders. Several studies have highlighted the related incidence of particular gastrointestinal symptoms (GISs) in children suffering from ASDs. Probiotics have shown success in treating several gastrointestinal dysbiotic disorders; therefore, it is plausible to investigate whether they can alleviate behavioral symptoms as well. On these bases, a randomized double-blind crossover study with a placebo was conducted, evaluating the effects of a mixture of probiotics in a group of 61 subjects aged between 24 months and 16 years old with a diagnosis of ASD. Behavioral evaluation was performed through the administration of a questionnaire including a Parenting Str...