A ‘giant’ paraganglioma in the testis (original) (raw)
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Paraganglioma in paratesticular: A rare case report
2024
Paraganglioma at a paratesticular location is extremely rare. We report a 58-year-old Saudi male presented with two years history of right painless scrotal mass. On physical examination the scrotum revealed a right-sided non-tender mass not attached to right testis. Normal tumor markers of testicular tumor. Ultrasonography revealed a well-defined, homogeneous, hyperechoic lesion measuring approximately 2 cm in the right extratesticular region. Magnetic resonance imaging (MRI) with intravenous (IV) gadolinium contrast for abdominal and pelvis showed right extratesticular soft tissue mass not separable from the spermatic cord and there was no distant metastasis. The patient underwent exploratory excision of the mass with preservation of cord and testis. Histopathology showed paratesticular paraganglioma.
Primary paraganglioma of seminal vesicle
International Journal of Surgery Case Reports, 2013
INTRODUCTION: Paragangliomas are rare tumors arising from neural crest tissue located outside the adrenal gland. Primary seminal vesicle paraganglioma is extremely rare entity. PRESENTATION OF CASE: A 26-year-old male patient presented with symptoms and signs of acute appendicitis where a CT of abdomen and pelvis showed an inflamed appendix and incidental finding of left seminal vesicle mass. The patient underwent uneventful laparoscopic appendectomy followed by transrectal ultrasound (TRUS) guided seminal vesicle biopsies. Histopathology revealed a neuroendocrine neoplasm consistent with paraganglioma. Surgical excision of the left seminal vesicle was carried out. DISCUSSION: Paraganglioma of genitourinary tract is rare. The urinary bladder is the most common site, followed by the urethra, pelvis and ureter. Seminal vesicle paragangliomas were reported in association with other genitourinary organ involvement such as bladder and prostate. Isolated seminal vesicle paraganglioma is extremely rare and surgical excision remains the standard treatment for localized paraganglioma. CONCLUSION: Primary tumors of seminal vesicle are rare and represent a diagnostic challenge. Differential diagnosis includes a list of benign and malignant tumors. Primary seminal vesicle paraganglioma is a rare but important diagnosis to be included in the differential diagnosis.
Sao Paulo Medical Journal, 2012
CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
Extra-adrenal paraganglioma of prostate
Canadian Urological Association Journal, 2013
Extra-adrenal pheochromocytomas, or paragangliomas are rare tumors that may develop from extra-adrenal chromaffin cells, and most occur in the organ of Zuckerkandl. Extra-adrenal paraganglioma of the prostate is extremely rare. Here, we report a 53-year-old man with hypertension and lower urinary tract symptoms, who was initially diagnosed as benign prostate hyperplasia. Computed tomography (CT) showed a large heterogenously enhancing mass in the prostate, imprinting the right distal ureter and urinary bladder. Before surgical intervention, CT-guided biopsy of the prostatic mass was performed and the result of histologic examination confirmed extra-adrenal paraganglioma. He underwent radical prostatectomy, partial cystectomy and right ureteroneocystostomy. The patient recovered and his blood pressure returned within normal range after surgical removal of the prostate tumor. In this article, we stressed that the rarity of prostatic paraganglioma, preoperative localization, and imagin...
Benign and Malignant Neoplasms of the Testis and Paratesticular Tissue
Surgical Pathology Clinics, 2009
B enign and malignant tumors of the testes and paratesticular tissues present an interesting spectrum of diagnostic entities often encountered in routine surgical pathology practice. Germ cell tumors are the most common tumors of the testes and, despite a rising incidence, have excellent prognosis because of their radiosensitivity and/or effective chemotherapeutic agents. The proper classification of these tumors aids in the choice of appropriate treatment options. This article reviews benign and malignant neoplastic entities of the testes and paratesticular tissues and illustrates the classic pathologic characteristics. The differential diagnosis, ancillary studies, clinical significance, and presentation are discussed also.
2016
Objectives: To study the prevalence and histomorphologic spectrum of tumor and tumor like lesions of testis and paratesticular tissues. Material and Methods: This was a prospective study conducted involving 59 cases. The clinical details were recorded from the case records. Each specimen was subjected to detailed gross examination and the histopathological features were noted on hematoxylin and eosin stained slides of all the specimens. The clinical data, macroscopic and microscopic findings in these cases were tabulated and analyzed. Descriptive parameters like mean, percentage etc were calculated using SPSS software. Results: Prevalance of testicular tumors was 0.26%. Right testis [31 cases (52.54%)] was involved more commonly than the left [28 cases (47.45%)]. Majority of the testicular lesions were tumor like lesions comprising of 41(69.50%) of the cases followed by tumors which accounted for 18 (30.50%) cases. Seminoma was the commonest of germ cell tumor (33.30%) followed by 27.70% of germ cell tumor of more than one histologic type. Non-specific orchitis was commonest of all tumor like lesions (54.23%) followed by tuberculous orchitis. There were one case (5.60%) each of adenomatoid tumor and rhabdomosarcoma involving paratesticular region. Conclusion: Tumor and tumor like lesions of testis have similar presentations in the form of scrotal swelling and pain. Majority of the testicular lesions were tumor like lesions. Among tumors seminoma was the commonest neoplasm. Histopathologic examination and routine hematoxylin and eosin staining can help in accurately diagnosing and determining the prognosis of these rare tumor and tumor like lesions of testis and para testicular region.
Paraganglioma of the prostate in a young adult
Urology, 2005
Extraadrenal pheochromocytomas, or paragangliomas, are rare and potentially malignant tumors that may occur in extraadrenal chromaffin tissue. The determination of malignant or benign represents the crucial point once the diagnosis has been established. We report a case of a 33-year-old man with an incidental paraganglioma involving the prostate. He underwent nerve-sparing radical retropubic prostatectomy and monolateral lymphadenectomy. Urinary continence was complete on postoperative day 5, and the patient had intercourse 2 weeks after surgery. The follow-up was at 24 months with no evidence of recurrent disease on clinical examination or body scan evaluation.
Prevalence of Testicular and Paratesticular Tumours: A 10-year Study
National Journal of Laboratory Medicine, 2020
Other non-neoplastic lesions of these sites, extragonadal germ cell tumours and already treated cases were excluded. Relevant data such as the age of patient, clinical presentation, radiologic findings, serum levels of tumour markers, gross findings like type of orchidectomy, size of the tumour, colour, consistency as well as tumour extension into rete testis or spermatic cord,