Vesicular Ca 2+ Participates in the Catalysis of Exocytosis (original) (raw)

Vesicular monoamine transporter inhibitors were investigated for their effects on catecholamine release in bovine chromaffin cells, revealing that certain inhibitors significantly decreased both exocytotic frequency and the rise in intracellular Ca2+. Interestingly, the study found that vesicular Ca2+ is not only critical for initiating exocytosis but can also be mobilized under specific conditions, contributing to the pool of intracellular calcium available for the release process. These findings highlight the dual role of vesicular Ca2+ during exocytosis, suggesting that vesicular stores may function as a source of calcium that modulates neurotransmitter release.