Food Allergy in the Horse: A Dermatologist's View (original) (raw)
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Horse-meat allergy mediated by dog-allergy: a case report and review of the literature
Allergo journal, 2016
e pork-cat syndrome is an IgE-mediated allergy to pork triggered by a primary sensitization to cat dander. IgE-antibodies are directed to cat serum albumin, Fel d 2, and cross-react with porcine serum albumin. In contrast to meat anaphylaxis caused by IgE to α-Gal, in patients with pork-cat syndrome, symptoms occur in less than two hours a er consumption. As albumin is a thermolabile allergen, patients o en tolerate well done meat. In this review, di erent allergens of red meat are described and an original case of allergy to horse meat mediated by allergy to dog dander is presented.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 2015
Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses. Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2-224511), previously shown to be associated with RAO. The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO-affected Warmblood horses and 264 RAO-unaffected controls. All horses were Warmbloods, 14 years or older. Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2-224511 as well as management and environmental factors were investigated. In P1, RAO-affected horses had a 13.1 times hi...
International Archives of Allergy and Immunology, 2011
dander underwent a detailed interview concerning clinical history, pet ownership and possible exposure. Results: Data from 3,235 outpatients were collected and 2,097 had at least 1 skin positivity. Among them, 113 (5.38%) were sensitized to horse dander (9 monosensitized). Thirty patients reported direct horse contact (4 owners and 26 for riding or occasional contact), 23 patients were sometimes in contact with horse owners and 60 subjects denied any direct or indirect exposure. Among 9 horse monosensitized patients, 6 had intermittent and mild rhinitis and 3 persistent moderate/severe rhinitis plus asthma. Three of them were horse owners or riders and the remaining had no contact with the animal. Conclusions: Our data evidence that the rate of sensitization to horse dander is not negligible and probably underestimated. In susceptible, not occupationally exposed individu
Measurement of Horse Allergens Equ c 1 and Equ c 2: A Comparison among Breeds
International Archives of Allergy and Immunology
Introduction: Horse allergens are less studied than allergens from other furry animals and these allergens must be evaluated to understand the complexity of allergy to horses. The aims of this study were to develop assays for the horse allergens Equ c 1 and Equ c 2 in dander and saliva and to determine their levels in ten horse breeds. The study also included a comparison of these findings with previous results on the levels of Equ c 4 performed on the same study population. Method: The study population included 170 horses from 10 horse breeds including American Curly and Russian Bashkir horse, which have been suggested to be hypoallergenic. Competitive ELISA assays were developed, with polyclonal antibodies as capture antibodies, for the detection of Equ c 1 and Equ c 2 in dander and saliva samples. Results: The horse allergens Equ c 1 and Equ c 2 were found in all dander and saliva samples from the ten horse breeds. The GM level (ng/µg protein) of Equ c 1 in dander was 470 (range ...
Assessment of serum allergenspecific IgE levels in horses from Siedlce County, Poland
Veterinarska stanica
The aim of the present study was to determine the frequency of different allergies in horses from central Poland. Allergic diseases are common in horses all over the world. Common conditions that have been associated with immunoglobulin E (IgE)-mediated allergy in horses include insect bite hypersensitivity (IBH), urticaria and recurrent airway obstruction (RAO). A variety of serological assays are available to measure serum levels of allergen-specific IgE antibodies. They can provide supportive evidence for a diagnosis of equine allergic dermatitis associated with environmental allergens. This study was performed on clinically healthy, Polish noble half-breed horses. In this study, four groups of allergens were identified as commonly inducing allergic reactions: American house dust mites (D. farinae), cultivated plants (rape), English plantain (Plantago lanceolata) and biting midges (Culicoides nubeculosus). More than 50% of horses showed positive reactions to these groups of aller...
Food allergy and atopic eczema
2010
The subject of food allergy is still viewed with considerable scepticism by the medical profession. There are several reasons for this but probably the most important is that few physicians or ecologists have yet made a serious attempt to analyse the condition critically. Food allergy is discussed in a number of books mostly emanating from the USA, particularly those by Rowe (1931), Coca (194z), Rinkel et al. (1951) and Dickey (1976). Unfortunately, each author uses the term 'food allergy' to describe both immunological and non-immunological phenomena, whereas most physicians would now reserve the term for hypersensitivity reactions to foods, particularly those mediated by IgE. Foods may cause clinical manifestations for three main reasons: I. The patient is intolerant of foods containing substances which (a) have a pharmacological action (e.g. caffeine, tyramine) (b) release chemical mediators (e.g. histamine) (c) are toxic (e.g. acetanelide in rapeseed oil) (d) are irritant to the intestinal mucosa, especially if it is already diseased 2. The patient has an enzyme deficiency in the intestine such as lactase at https://www.cambridge.org/core/terms.
Journal of Small Animal Practice, 2010
OBJECTIVES: To determine the prevalence of adverse food reactions (AFRs) in dogs with dermatological signs presented to the referral dermatological clinic of the University of Milan. METHODS: The medical records of dogs with dermatological signs were reviewed. Prevalence of AFRs was calculated. Owner and clinician pruritus scores were compared. Breed, sex and age predisposition were statistically tested, as was the association between AFR and selected clinical features. RESULTS: The prevalence of AFRs in dogs with dermatological signs was 12% (16 of 130). AFR was diagnosed in 26% of dogs with allergic disease and 48% of those subjected to a dietary trial. There was a significant association between AFRs and early onset of clinical signs (<1 year) (OR=3•8; P=0•0221, 95% CI=1•27 to 11•16). There was a significant association between AFRs and both otitis externa (OR=5•9; P=0•0015, 95% CI=2 to 17•9) and perianal fistula (OR=26•1; P=0•0058, 95% CI=2•52 to 269•4), although all dogs with perianal fistulas were German shepherd dogs. CLINICAL SIGNIFICANCE: The prevalence of AFRs in the study population was higher than most reported values. Further studies are warranted to investigate the true prevalence of AFR and its possible association with perianal fistula and other potential markers.
Retrospective study of diagnosis of cutaneous adverse food reaction in 149 pruritic dogs
This was a retrospective study of two groups of cases using commercial hydrolysate diet and homemade diet in the diagnosis of cutaneous adverse food reaction in 149 pruritic dogs by food restriction trial and food challenge. There was no statistically significant difference in frequencies of food-sensitized dogs, non-food-sensitized dogs, and dropped out cases between these two groups (p > 0.05). Seventy-one dogs (47.65%) completed the trial, 43 dogs had shown no reaction to any foods. Food hypersensitivity had been diagnosed in 28 dogs. Offending food allergens identified by food challenge of these 28 dogs were as follows: chicken meat (18), pork (9), commercial dry foods made from chicken, beef, etc. (8), chicken entrails (8), cow's milk (4), beef (2), dog's snack (2), pig entrails (1), shrimp (1), fish (1), duck (1), egg (1), and bread (1). Each dog with food hypersensitivity was allergic to 1-4 different food allergens.