Exercise improves aging-related decreased angiogenesis through modulating VEGF-A, TSP-1 and p-NF-Ƙb protein levels in myocardiocytes (original) (raw)
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Angiogenesis: Role of Exercise Training and Aging
Adaptive Medicine, 2010
Angiogenesis, formation of new blood vessel from the pre-existing vessel is crucial for cell survival in tissues. Vascular endothelial growth factor (VEGF) plays a predominant role in angiogenesis. Altered angiogenic factors results to impair the angiogenesis process that leads to various pathological conditions in aging. Previous findings on age-induced alterations in VEGF signaling and other angiogenic factors are inconsistent. Changes in VEGF and other angiogenic factors shift the homeostasis between stimulation and inhibition in angiogenesis. Earlier studies demonstrated that age-related impaired angiogenesis in different tissues can be reversed, to some extent, by exercise training. In this review, we emphasized the effect of exercise on VEGF family and other angiogenic factors, and the possible mechanism underlying to such adaptive response was also described. Age-related change in VEGF action takes part in the developments of cardiovascular disease, neuromuscular disorders and skeletal muscle damage. Exercise training has been shown to reverse the age-associated deteriorations, which suggest that exercise is essential to maintain the good quality life at any age.
Citation: Titiporn Mekrungruangwong, Pimpetch Kasetsuwan, Sheepsumon Viboolvorakul, Suthiluk Patumraj. Protective Effects of Exercise Training Against Aged-Induced the Reduction of Cardiac Angiogenic Capacity in Middle-Aged Rats. Cardiology and Cardiovascular Medicine 4 (2020): 058-065. Abstract Objective: To investigate the protective effects of exercise training against aged-induced the reduction of cardiac angiogenic capacity associated with VEGF, phospho-Akt1, and eNOS in middle-aged rat hearts. Methods: Rats were divided into three groups: Sedentary-young group (aged 4 months), Sedentary-middle-aged sham group (aged 14 months), and Exercise-trained middle-aged group. In the younger group, rats were subjected to the same swim environment as the trained-aged animals, except they were remained freely in their cages. In sham group, rats were immersed in cylindrical tanks filled with water to a depth of 5 cm that controlled temperature at 33-36 o C for 30 minutes/day, 5 days/week for 8 weeks. In Exercise trained-middle-aged group, rats swam in cylindrical tanks filled with water to depth of 50-55 cm-controlled temperature at 33-36 o C for 60 minutes/day, 5 days/week for 8 weeks. To evaluate the malondialdehyde level (MDA), the thiobarbituric acid reactive substances assay (TBARS) were used in this
Protective effects of exercise training against agedinduced the reduction
Citation: Titiporn Mekrungruangwong, Pimpetch Kasetsuwan, Sheepsumon Viboolvorakul, Suthiluk Patumraj. Protective Effects of Exercise Training Against Aged-Induced the Reduction of Cardiac Angiogenic Capacity in Middle-Aged Rats. Cardiology and Cardiovascular Medicine 4 (2020): 058-065. Abstract Objective: To investigate the protective effects of exercise training against aged-induced the reduction of cardiac angiogenic capacity associated with VEGF, phospho-Akt1, and eNOS in middle-aged rat hearts. Methods: Rats were divided into three groups: Sedentary -young group (aged 4 months), Sedentarymiddle-aged sham group (aged 14 months), and
Medical Laboratory Journal, 2023
Background and objectives: Considering the importance of aging and the associated physiological changes, as well as the effects of exercise on angiogenesis and cardiac index, this study aimed to compare continuous and periodic exercise in form of high-intensity interval training (HIIT) on serum levels of nitric oxide (NO) and vascular endothelial growth factor (VEGF) in old rats. Methods: In this study, 30 old male rats were randomly divided into three groups: continuous training (n=10), HIIT (n=10), and control group (n=10). Interventions were performed for 8 weeks. To evaluate the research variables, 72 hours before the first training session and after the last training session, 3 ml of blood were taken from the tails of the rats. One-way analysis of variance was used to analyze the findings and Levene's test was used for assessing the homogeneity of variance. All statistical tests were performed using SPSS 17 software at a significance level of 0.05. Results: Both training exercises significantly increased NO and VEGF levels compared to the control group (p<0.05). Conclusion: The results of this study showed that 8 weeks of continuous and interval training cause a significant increase in the level of angiogenic factors in old rats. Therefore, these exercises and especially alternative exercises can be used as a suitable way to increase angiogenesis in the elderly.
Exercise induces cardiomyogenesis in the aged heart
The Journal of Cardiovascular Aging, 2023
Availability of data and materials Not applicable. Financial support and sponsorship This work is supported by the center for regenerative science and medicine (CRSM) UTSW. Conflicts of interest Both authors declared that there are no conflicts of interest. Ethical approval and regulatory approval Not applicable.
European journal of preventive cardiology, 2015
A reduction in number and function of endothelial progenitor cells (EPCs) occurs in both physiologic aging and chronic heart failure (CHF). We assessed whether disease and aging have additive effects on EPCs or whether beneficial effects of exercise training are diminished in old age. We randomized 60 patients with stable CHF and 60 referent controls to a training or a control group. To detect possible aging effects we included subjects below 55 (young) and above 65 years (older). Subjects in the training group exercised four times daily at 60% to 70% of VO2max for four weeks under supervision. At baseline and after the intervention the number and function of EPCs were assessed. As compared with young referent controls, older referent controls showed at baseline a reduced EPC number (young: 190 ± 37 CD34/KDR positive cells/ml blood; older: 131 ± 26 CD34/KDR positive cells/ml blood; p < 0.05) and function (young: 230 ± 41 migrated cells/1000 plated cells; older: 185 ± 28 cells/100...
The Effect of Interval Training on Cardiac Angiogenesis Capacity in Rats with Myocardial Infarction
2019
Introduction: Myocardial infarction (MI) is the destruction and permanent and irreversible cell death of part of the cardiac muscle (myocardium) which occurs due to loss of blood flow to the heart. The condition disrupts individuals’ daily life and limits their performance. Evidence indicates the likely effect of exercise on increasing the capillary density of skeletal muscle and myocardium. Vascular endothelial growth factor (VEGF) and endostatin as well as their common receptors (Flt-1) are the most important factors involved in angiogenesis. Therefore, this research aimed to evaluate the effect of 6 weeks of interval training on the VEGF, Flt-1 and collagen 18 in rats with MI. Methods: 12 male Wistar rats with mean age of 10weeks and average weight of 250300 gr were infected with myocardial infarction and were assigned into two groups of (1) experimental (60 minutes of interval running on treadmill, each interval 4 minutes with the 6075 percent of Vo2max and 2 minutes of active r...