Magnetoferitín a Jeho Potenciálne Bioaplikácie (original) (raw)
2015
Obsah 1. Úvod 2. Magnetoferitín 3. Fyzikálno-chemické vlastnosti magnetoferitínu 4. Potenciálne bioaplikácie magnetoferitínu 5. Záver 1. Úvod Železo je esenciálnym prvkom živých systémov, pre-tože jeho nedostatok spôsobuje bunkovú smrť. Prebytok železa, najmä v podobe Fe 2+ iónov, je pre organizmus to-xický, preto je uskladnený v jadre zásobného proteínu, feritínu, kde sa železo ukladá vo forme hydratovaného železitého komplexného fosfátu [FeO(OH)] 8 [FeO(H 2 PO 4)] s kryštalografickou štruktúrou podobnou minerálu ferihydrit 1-3. Narušenie rovnováhy metabolizmu a uskladňovania železa vo feritíne úzko súvisí s rôznymi ochoreniami, aký-mi sú rakovinové alebo neurodegeneratívne ochorenia 4-7. Patologické zmeny sú sprevádzané prítomnosťou magneti-tu vo feritíne 8-14. Vzniknutá polykryštalická štruktúra feri-tínu môže hrať významnú úlohu v biochemických proce-soch, spojených s rôznymi chorobami. Doteraz nie je dos-tatočne preskúmané, či je vytvorenie biogénneho magneti-tu v mozgovom feri...
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