Chemical Characterization of an Ayurvedic Herbo-Mineral Formulation - Vasantakusumākara Rasa: A Potential Tool for Quality Assurance (original) (raw)
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Journal of evidence-based integrative medicine
Rasa Shastra is an exclusive branch of ayurveda that uses processed metals and minerals in various combinations. Though the formulations are time tested, safety and quality concerns are being raised since the past two decades. In view of this, it becomes mandatory to generate quality control profiles of such formulations by following available parameters. Considering this, we attempted to develop standard manufacturing procedures of Maha Yogaraja Guggulu and generate preliminary physicochemical profiles using inductively coupled plasma mass spectrometry, X-ray diffraction, and high-performance thin-layer chromatography. The results from high-performance thin-layer chromatography revealed presence of organic constituents from plant material. X-ray diffraction indicated that the prepared drug contained cinnabar (mercury sulfide; Rasa sindhura), cassiterite (tin oxide; Vanga bhasma), litharge (lead oxide; Naga bhasma), and iron dioxide and magnetite (di-iron oxide; Loha and Mandura bha...
Introduction-Inclusion of newer drugs in pharmaceutico-therapeutics of Rasashastra in different era has been evident. Many synthetic drugs are included in contemporary pharmaceutico-therapeutics of Rasashastra Aim of the study- To correlate classical Rasavarga Dravya with their representative synthetic compounds assumed to be by maximum scholars or being used today. Material and Methods- Classical Rasadravya were compared for source, acceptable varieties, possible chemical nature or composition and similarity, with their representative synthetic compound assumed to be by maximum scholars or being used in Pharmaceutico-therapeutics of Rasashastra in present era, from classical, contemporary Ayurvedic texts, modern texts and researches. Different varieties of same Rasadravya are correlated with other possible minerals, ores, alloys, principle compounds or chemical composition apart from assumption in presentera. Results and Discussion- Maximum number of Rasavarga Dravya shows similarity with their representative synthetic compound of Rasashastra in present era. Conclusion-Adoption of synthetic drugs in Ayurvedic pharmaceutico-therapeutics is beneficial in view of standardization, however for research purpose, possibility of different compounds or chemical composition apart from assumption in present era, should not be denied.
Ancient science of life, 2010
The one of the oldest system of medicine, Ayurveda is momentous in audience of worldwide on virtue of its holistic approach of life. Formulations of Ayurveda consist of substances of herbal, mineral/metal and animal origin which are processed pharmaceutical to have therapeutic effects. This is attribute of processes of Shodhan (purification/potentiation), Bhavana (impregation /levigation) and Marana (incineration/calcinations) of Rasa Shastra which acclimatize these toxic industrial matter to a effective remedies known as herbo mineral formulations (Rasaoushadhies) of Ayurveda. In recent past there is prevalence of some doubt on safety and efficacy of these medicines. In this review paper we tried to justify application of these medicines as these are time tested and showed wonderful clinical adaptability. We also attempted to establish new facts of figures of core science in explanation of these medicines.
Evaluation of an Ayurvedic Compound Formulation Laghusutasekhara Rasa
India has vast heritage of traditional system of medicines, but due to lack of scientific evaluation, the people are unable to utilize the benefits of it, particularly those people who cannot afford the modern medicine. The utmost efficacy of medicines as specified in Ayurvedic system can be achieved if each and every formulation mentioned in the system would be scientifically evaluated and their desired efficacy could be maintained. Therefore, an attempt has been made to evaluate Laghusutasekhara Rasa, an Ayurvedic compound formulation used in various diseases. One sample from manufacture was procured and subjected to macroscopic, microscopic, physico-chemical and TLC/HPTLC finger printing analysis using authentic ingredient as control. Microscopic and TLC/HPTLC finger printing analysis of the sample was found to complement each other and are sufficient for establishing the identity of raw materials in the compound formulation.
Journal of Ayurveda and Integrative Medicine, 2017
Background Mahamrutyunjaya rasa is an ayurvedic formulation used in the treatment of cardiac disorders. It contains the purified roots of Visa (Aconitum ferox), Brihati (Solanum indicum), fruits of Pippali Kana (Piper longum), Marica (Piper nigrum), Gandhaka (Sulfur), Hingula (Cinnabar) and Tankana (Sodium metaborate) as per Bhaishajya Ratnavali. The purification (shodhana) process changes the physiochemical properties of the raw materials which need to be studied and understood. Objective The present work aims to perform a comprehensive physicochemical characterization of raw materials, intermediates and the final product obtained during purification, using modern analytical techniques. Materials and methods The standard methods as per traditional text were followed and the physicochemical changes were also investigated by collecting samples at different steps of purification. The samples were analysed using various techniques, viz. Fourier transform infra-red spectroscopic (FTIR),...
Rasasastra is a branch of Ayurvedic medicine which deals with preparation of the drugs with metals and minerals having higher therapeutic efficacy with quick action in minute dose. Present preparation Anilari Ras is a herbo-mineral formulation used for treating all types of Vata disorders. This drug is a variety of Tamra bhasma (incinerated Copper) preparation processed with Shodit parad (Purified Mercury), Shodit Gandhak (Purified Sulphur), Shodit Tamra (Purified Copper) and Bhavana dravyas (liquids used for trituration) are Nirgundi patra swarasa (Vitex negundo Linn.), Eranda mula kashaya (Ricinus communis Linn) and Citraka mula kashaya (Plumbago zeylanica Linn). Triturating Rasa drugs with herbal liquids (Bhavana) increases the efficacy of formulation. Puta in the preparation imparts Laghutva (easily assimilating) property, helps in particle reduction and facilitates nano particle formation which enhances rapid action of the medicine. The pharmaceutically developed drug was subje...
European Journal of Preventive Medicine, 2015
Traditional or alternative medicines such as Ayurvedic drugs are getting importance and reputation day by day in the treatment of various diseases. This is because it has fewer side effects and gives necessary pharmacological action. But prolonged and excess usage may lead to harmful effects such as damage of the heart muscle leading to various types of arrhythmia and coronary artery diseases. "Khadirarista", an Ayurvedic drug, was traditionally used for heart diseases along with jaundice, anemia, abdominal tumor and leprosy. The physicochemical properties such as pH, density, viscosity, conductivity, loss on drying (LOD), chromatographic and spectral study, and presence of metal ions the drug "Khadirarista" were studied. It was found that pH values were 4.53, 4.21 and 4.31 at 1%, 5% and 10% of test solution, respectively. It indicated that "Khadirarishta" was an acidic preparation. Density, average viscosity and residue (LOD) of the drug was 1.0076 g/mL, 25.22 pascal/second and 9.33 g/100 mL, respectively. The spectral study of the test sample was performed and peaks were obtained at the wavelengths of 275, 254, 274.80, 254.60, 275.60, 273.60, 211, 253.60 nm in UV spectrophotometer with 276.60 nm being the λ max. HPLC analysis of the sample was performed and retention time (R t) of the possible active components were found to be 4.12, 4.22 and 4.83 min. R t at 4.12 min was the most sharp peak. Applying TLC, the R f values of the active compounds were found to be 0.6 and 0.7. The level of various metal ions in the sample was measured by Flame Photometry and Na, K, Ca levels were found to be 75 ppm, 5 ppm, 12 ppm, respectively.
A CRITICAL REVIEW OF PHARMACEUTICO-ANALYTICAL WORKS DONE ON RASAMANIKYA (A SPECIAL DRUG OF AYURVED
PHARMAAYURVED ONLINE RESEARCH JOURNAL FOR PHARMACY, AYURVED AND ALLIED SCIENCES http://www.pharmaayurved.in/ Ayurveda, which is known as "the Science for long life" is an Indian System of Medicine. Soon after Ayurveda began to mingle herbs-metals and other "toxic" minerals, metals and nonmetals as important mechanism of pharmaceutical preparations, among that arsenic compounds are being popularly used in Ayurveda therapeutics since centuries, Haratala (Orpiment) is widely used in various forms (Shodhita, Bhasma and Rasamanikya) being commonly used in treating the diseases like Sleshmaroga, Raktapitta, Vatarakta, Kustha etc. Rasa Manikya is one such preparation in Rasa Shastra which is prepared just by changing the nature of a compound exhibits light micro fine powder, prepared by processing only Shuddha Patra Haratala churna. Different opinions about preparations of Rasamanikya are available in the texts showing prominent changes in the chemical composition of final product. Keeping this point in mind various types of research works on Rasamanikya have been carried out and published in many of the internal peer reviewed journals. Therefore here an attempt is made to compile those studies so that some conclusions can be drawn to identify the Rasamanikya and its chemical composition.
Tarakeshwara Rasa (TR) is an Ayurvedic herbomineral compound formulation used in the intervention of Prameha vis-à-vis diabetes mellitus. The present study was executed to establish a fingerprint for this unique formulation, which can be adopted by the Ayurvedic pharmacies for drug standardization. TR is a formulation prepared by the trituration of four ingredients Abhraka Bhasma (AB), Loha Bhasma (LB), Vanga Bhasma (VB) and Rasa Sindhura (RS) in equal quantities with honey for one day. Each of the ingredients were prepared according to the norms of Ayurvedic classical texts and by employing Electric Muffle Furnace as heating device for incineration. To ensure the proper preparation of Bhasmas, standard tests (Bhasma Pariksha) were employed. After Bhasma complies these tests, TR was prepared and subjected for qualitative analysis, X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) studies. LB, AB, VB, RS and TR were also studied for free metal presence by employing phosp...