Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer (original) (raw)
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Medical oncology (Northwood, London, England), 2006
The identification of a reliable circulating tumor marker in squamous cell carcinoma of the head and neck (SCCHN) could assist in diagnosis and monitoring response to therapy. The aim of this study was to investigate the effectiveness of the serum tumor markers CYFRA 21-1, TPA-M, SCCA, and CEA. Serum levels of CYFRA 21-1, TPA-M, SCCA, and CEA were measured in 136 patients with a histologically proven SCCHN before and after treatment and in 125 healthy subjects, as controls. We evaluated the sensitivity and specificity of these tumor markers and to correlate their levels with tumor staging, grading, or performance status. The study showed that none of the above markers presented satisfactory specificity and sensitivity in early diagnosis. In comparison with the other markers, TPA-M was the most effective of all markers and indicated a positive correlation with the grade of differentiation and nodal status. A remarkable correlation between high levels of TPA-M and CYFRA 21-1 in advanc...
Anticancer research, 2015
Establishing prognostic factors is very important in the management of cancer patients. Our aim was to evaluate the clinical significance of a panel of tumor markers, including CEA (Carcino Embryonic Antigen), SCC (Squamous Cell Carcinoma Antigen), TPS (Tissue Polypeptide Specific Antigen) and CYFRA 21-1 in head and neck cancer patients, for assessing treatment response and prognosis of patients. We evaluated 312 blood samples from 143 head and neck cancer patients, from several sub-groups: 82 Larynx Carcinoma pre- and 38 post-therapy, 46 Oral Cavity pre and 29 post-therapy, 12 nasopharynx, 16 parotid and other salivary gland patients. Blood tumor markers levels were evaluated by conventional ELISA assays. Correlations of marker levels to stage of disease, lymph node involvement and therapy, were performed. Serum levels of all four tumor markers were higher before therapy and decreased thereafter in all patients. The decrease in TPS level following therapy was significant (p=0.03). ...
Preoperative SCC Antigen, CRP Serum Levels, and Lymph Node Density in Oral Squamous Cell Carcinoma
Medicine, 2016
The prognostic significance of squamous cell carcinoma antigen (SCC-Ag) and C-reactive protein (CRP) levels and lymph node density (LND) has been individually recognized in oral squamous cell carcinoma (OSCC). We investigated the relationship between preoperative serum markers (SCC-Ag and CRP) and postoperative prognostic marker (LND) in this study. We retrospectively analyzed 277 OSCC patients who underwent primary curative resection and neck dissection with/or without adjuvant therapy between March 2008 and November 2013. Serum SCC-Ag and CRP levels were measured preoperatively. Distant metastasis, overall survival (OS), and disease-free survival (DFS) were used to evaluate the prognostic significance of preoperative SCC-Ag and CRP levels in relation to LND. LND (cutoff point ≥0.06) correlated with the pathologic tumor status, pathologic nodal metastasis, degree of differentiation, tumor stage, tumor depth (≥10 mm vs <10 mm), and perineural invasion (all P values were <0.001...
Oral Diseases, 2013
OBJECTIVE: To evaluate serum levels of interleukin (IL)-1, IL-6, IL-8, IL-10, soluble IL-2 receptor (sIL-2R), squamous cell carcinoma antigen (SCCA), tissue polypeptide-specific antigen (TPS) and vascular endothelial growth factor (VEGF) in patients with potentially malignant disorders (PMD), oral squamous cell carcinoma (OSCC), or status-post (SP) OSCC. SUBJECTS AND METHODS: Blood was collected from 47 patients, either controls or diagnosed with PMD, OSCC, or SPOSCC. Levels of cytokines and tumor marker were evaluated by ELISAs. Normal levels were based on previous studies and pathology determined by chi-square and Fisher's exact tests. P ≤ 0.05 was considered statistically significant. RESULTS: Above normal levels of SCCA were found for OSCC and dysplasia patients (33.3% and 11.1%, respectively) and high range of normal (upper 20% of the normal range) for lichen planus, SPOSCC, and dysplasia patients (6.67%, 33.3%, and 22.2%, respectively), differences that approached statistical significance (P = 0.055). No differences were found between groups for other tested markers. A progression was seen for SCCA from high range of normal in SPOSCC to a mixture of high normal and elevated in dysplasia to elevated in active OSCC, suggesting that SCCA may be correlated with cancer progression. CONCLUSION: Higher levels of serum SCCA may serve as a marker for dysplasia and progression to oral carcinogenesis.
Biomarkers profile of oral squamous cell carcinoma
Practica medicală, 2020
More than 95% of oral cancers are represented by squamous cell carcinomas (OSCC). Despite the serious progress concerning the oral cancer treatment made in the last decade, the OSCC prognosis remains poor. Currently, the OSCC detection and diagnosis is mainly based on clinical oral examination combined with biopsy for a histopathological examination if a suspect area is detected. Our study has included 20 patients (12 females and 8 males) diagnosed with OSCC. TAC, OXSR1 and MMP-9 were measured in the tumoral cells lysates by ELISA. Our results revealed that the MMP-9 levels were significantly and negatively correlated with OXSR1 levels. Also, our study results illustrated a significant positive correlation of TAC with OXSR1. In conclusion, corroborating our findings with literature reports, we can outline that OXSR1 and MMP-9, together, possibly, with TAC, could be regarded as new steps in order to elaborate diagnostic tools for early detection OSCC.
Prospective study of characteristic of patients with Oral squamous cell carcinomas
innovative publication, 2017
Background: Oral squamous cell carcinomas (SCC) still a significant health burden in developed and developing countries. Aims and Objectives: To study the premalignant and malignant lesions of oral cavity, to classify malignant lesions according to histomorphology and to study the expression of epidermal growth factor receptor (EGFR) in lesions. Materials and Methods: Fifty cases of SCC diagnosed by histopathology of oral cavity were studied in the Department of Pathology, Himalayan Institute of Medical Sciences, Dehradun over a period of 12 months. Semi-quantative evaluation of EGFR expression was done. All scores were based on examining the whole section in each biopsy under a multi headed microscope by three observers. Results: Out of 50 patients, 28% were in the age group of 51-60 years, there was an obvious male preponderance (92%). Majority of patients were only tobacco smokers (44%). The commonest site of oral cancers was tongue (26%). Out of total 50 cases, 37 (74%) were malignant and 13 (26%) were premalignant lesion. In present study, 48.64% of malignant and 84.61% premalignant lesion patients showed 3+ positivity of EGFR expression. Conclusion: Oral SCC was most common in male elderly patients, tongue was the most common site and moderately differentiated SCC was most common. Expression of EGFR was increased in both premalignant and malignant lesions. EGFR expression was over expressed in premalignant lesions and decreased in normal mucosa so premalignant lesions can be segregated as they are likely to progress to invasive cancer.
Oral squamous cell carcinoma: diagnostic markers and prognostic indicators
2016
OSCC is the most frequent malignant tumour of the oral cavity, accounting for more than 90% of malignant tumours of this anatomic region and it often arises from precursor lesions. Aside from tobacco and alcohol consumption, further determinants have been considered to increase the risk of OSCC development, such as micronutrient deficiencies, chronic traumatism, poor oral hygiene and viruses. Recurrence, survival and conversely, mortality depends on numerous and different biological, histological, macroscopic and microscopic factors that have been investigated in order to define causes, to help diagnosis and to refine appropriate treatments that perfectly fit with the different features of OSCCs. For this purpose, during the last decades, the improvement of scientific technologies and molecular analyses have allowed to investigate markers and genetic and epigenetic factors, in order to clarify their responsibilities related to early diagnosis and OSCC progression and prognosis in or...
Estimation of salivary biomarkers in patients with squamous cell carcinoma
2019
Introduction: Squamous cell carcinoma (SCC) is an epithelial malignancy that occurs in organs that are normally covered with squamous epithelium which includes several different anatomic sites. The present study was conducted to determine the role of salivary biomarkers in detection of SCC. Methods: The present study was conducted on 62 cases of oral squamous cell carcinoma of both genders. Subjects were divided into 2 groups. Group I had SCC patients whereas group II had control. Unstimulated whole saliva was collected and CYFRA 21‐1 and CA19‐9 were estimated by ELISA method while LDH level was assessed based on standard kit method. Results: Out of 62 patients, males were 42 and females were 20. The mean salivary biomarkers levels of LDH in group I was 424.8 and 112.5 in group II, CA19‐9 was 22.4 in group I and 20.5 in group II and CYFRA 21‐1 was 18.5 in group I and 3.6 in group II. The difference was significant (P< 0.05). Conclusions: Authors found raised level of LDH and CYFR...