Synthesis of 2H-1,2,3-Triazoles (original) (raw)

1,2,4-TRIAZOLES: Synthetic Strategies and Pharmacological Profiles

International Journal of Pharmacy and Pharmaceutical Sciences

Multicomponent, solid-phase, microwave and grinding methods are the constructive modes in the sustainable synthesis of 1, 2, 4-triazoles and such reactions have attracted enormous interest in recent years. The alternative reaction conditions getting popularity in the recent ecofriendly-economical time have been thoroughly investigated. Literature studies on 1, 2, 4-triazoles have shown that these derivatives possess broad spectrum of biological activities. This review focuses on synthetic strategies and pharmacological properties of 1, 2, 4-triazoles.

Recent advances in the chemistry of 1,2,4-triazoles: Synthesis, reactivity and biological activities

Tetrahedron Letters, 2021

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1,2,4-Triazoles: A Review of Synthetic Approaches and the Biological Activity

Letters in Organic Chemistry, 2013

1,2,4-Triazoles and their derivatives have a distinct place in the field of medicinal and pharmaceutical chemistry. These are used as lead compounds for the synthesis of numerous heterocyclic compounds which possess diverse biological activities and play pivotal roles. This review covers the latest literature and knowledge on the synthetic procedures for various triazoles derivatives, their activities and pharmacological applications.

2,4-TRIAZOLES: SYNTHETIC STRATEGIES AND PHARMACOLOGICAL PROFILES Review Article

International journal of Pharmacy and Pharmaceutical Sciences, 2014

Multicomponent, solid-phase, microwave and grinding methods are the constructive modes in the sustainable synthesis of 1, 2, 4-triazoles and such reactions have attracted enormous interest in recent years. The alternative reaction conditions getting popularity in the recent ecofriendlyeconomical time have been thoroughly investigated. Literature studies on 1, 2, 4-triazoles have shown that these derivatives possess broad spectrum of biological activities. This review focuses on synthetic strategies and pharmacological properties of 1, 2, 4-triazoles.

Recent advances in the synthesis of triazole derivatives

Afinidad, 2015

Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems. The triazole compounds possess a wide range of biological activities and are especially focused for antifungal behavior. In this review article, we have summarized the recent developments in the synthetic methodologies of this ring system. The main focus was on the methodologies which deal with the facile and convenient synthesis.

A novel approach to the synthesis of 1,2,3-triazoles and their SAR studies

Medicinal Chemistry Research, 2010

A series of biologically active 4-acetyl-2-aryl-5-methyl-1-vinyl-2,3-dihydro-1H-1,2,3-triazole derivatives has been synthesized. The compounds were synthesized in excellent yields (80-85%) and the structures were established on the basis of corresponding IR, 1 H NMR, and elemental analysis data. The purity has been ascertained on the basis of chromatographic resolution using acetic acid-toluene (4:6 v/v) as binary eluent. All the compounds (4a-l) have been tested for their antifungal activity against a representative panel of fungal microbes. These synthesized compounds exhibited significant activities against A. niger, C. albicans, C. azyma, and A. flavus. For all the tests conducted, voriconazole was used as the control drug. The hydrophobic parameter (log P) also has been quantized for correlation of structure with biological activity, and a critical evaluation of structure-activity relationship (SAR) has been performed.

2,3-Triazoles: A Review on Current Trends in Synthetic and Biological Applications

The chemistry of 1,2,3-triazoles gained much attention since the discovery by Pechmann, since then several protocols have been developed for the synthesis of 1,2,3-triazoles, but after the copper catalyzed alkyne-azide cycloaddition (CuAAC) reaction, the mainly because of Huisgen's 1,3-dipolar cycloaddition reactions, it has evolved to become one of the most successful connective linkers and functional heterocyclic cores in modern organic chemistry. This review summarizes the up-to date developments in the synthetic methodologies and their biological applications, in particular of antimicrobial, anticancer, anti-inflammatory, anti-proliferative, antidiabetic properties of 1,2,3-triazoles. Also, the progress in the molecular hybridization; and physic-chemical properties have been highlighted.

A new approach to the synthesis of functionalized 1-alkenyl-1 H-1,2,3-triazoles

Tetrahedron, 1998

~bstiuctz The Homer-Wadsworth-Emmons (HWE) olefination of l-[(dietboxyphosphoryl)methyl]-4,5-bis(methoxycarbonyl> lH-1,2,3-triazole and l-[(diethoxyphosphoryl)metbyl]-Sphenyl-1 H-1,2,3triazole by means of aldehydes was found to be a convenient method for the preparation of functionalized 1-alkenyl-lH-1,2,3-triazoles in moderate to good yields and low Z/E stereoselectivity.

Synthetic Trends Followed for the Development of 1,2,3-TriazoleDerivatives

International Journal of Drug Development and Research, 2017

1,2,3-triazoles find their application in the diverse areas of medicine. Enough literature is available demonstrating antibacterial, antifungal, anticonvulsant, antiviral, antidiabetic and antimalarial potential. Owing to their wide application, scientists across the globe are engaged in the design and development of 1,2,3-triazole based medicinal agents. However, the approach for development of such agents involving Huisgen’s cycloaddition reaction has gained immense importance. This manuscript covers different conventional and non-conventional approaches adopted for the synthesis of 1,2,3-triazole derivatives.